Manchester City midfielder David Silva has joined the growing injury list at the Etihad Stadium and looks set to miss the next few weeks as a result of a muscle problem.
City are already without influential Kevin de Bruyne, who has missed most of the season so far because of two knee injuries, and Sergio Aguero.
Silva was forced out of City's Premier League loss against Chelsea on Saturday evening after just 68 minutes and it is estimated the 32-year-old Spaniard will now be sidelined for around three weeks, effectively the rest of the calendar year.
Danilo will also be missing, while Benjamin Mendy is a long-term absentee. Oleksandr Zinchenko could return after his sitting out the Chelsea game with a broken nose.
City have already qualified for the Champions League knockout stages and just a draw with Hoffenheim at the Etihad on Wednesday night would be enough to secure top spot in the group and a place among the seeds for the Last 16 draw in the New Year.
The problem for City comes when Premier League action resumes at the weekend and they have to face Everton in Saturday's early kickoff. Silva and De Bruyne will both still be out, with Guardiola admitting there is only 'maybe a chance' that Aguero could be back.
City have incredible talents to call upon, but asking any team to survive without its three best and most important players is tough. After losing against Chelsea and being overtaken by a still unbeaten Liverpool in the Premier League table, the pressure is on for the reigning champions.