Los Angeles FC will face San Jose Earthquakes in the final match of the US Open Cup round of 16, with the winner set to encounter Portland Timbers in the quarter-finals of the oldest ongoing national competition in the United States.
Portland Timbers and the winner of tonight's game join Orlando City SC, New York City FC, Atlanta United FC, Saint Louis FC, Minnesota United FC and New Mexico United as the final eight, with the quarter-finals set to begin on July 10.
Here's a roundup of all the action that has taken place in the US Open Cup so far.
Starting on May 7-8, the first round of the tournament began with 38 teams from USL League One, USL League Two, National Premier Soccer League and eight local qualifiers. 25 teams from USL Championship entered in the second round the following week, with the third round taking place on May 28-29.
Local qualifiers Florida Soccer Soldiers went as far as the third round, defeating Miami FC 2-1 and Charlotte Independence 5-4 on penalties, following a 2-2 draw. They were eventually overcome 1-0 by USL Championship side North Carolina, ending a fantastic run for the semi-professional side, who were founded only last year.
Another dramatic run saw Orange County FC's charge to the fourth round. The National Premier League Soccer side conquered FC Golden State, local rivals Orange County SC and Las Vegas Lights, until LA Galaxy in the fourth round proved too much of an obstacle, losing 3-0.
The 21 American teams from the MLS entered the US Open Cup in the fourth round on June 11-12., where there were plenty of dramatic encounters.
New England Revolution defeated New York Red Bulls 3-2, despite being down to ten men. Despite Luis Caicedo's red card, forward Teal Bunbury bagged his second of the game to seal the win in extra time.
There was more drama in Washington, where D.C United scored two goals at the death to overcome Philadelphia United. With the score 0-0 after normal time, Anthony Fontana scored for the away side, before goals in the 118th and 120th minute from, respectively, Chris McCann and Manchester United legend Wayne Rooney secured a last-gasp win.
Elsewhere, New Mexico United scored a last minute equaliser before beating Colorado Rapids 4-2 on penalties. Devon Sandoval opened the scoring three minutes in, before the Rapids scored twice and had Axel Sjoberg sent off. Jamaican forward Kevaughn Frater dramatically equalised in the fourth minute of extra time, allowing New Mexico to secure the victory in the shootout.
Round of 16
In the standout game of the round of 16, Portland Timbers defeated an LA Galaxy side, without talisman Zlatan Ibrahimovic, 4-0.
20-year-old Brandon Vazquez elevated himself to joint-top scorer in the competition with a brace for Atlanta United FC against Columbus Crew FC in a 3-2 victory, while Minnesota United fought back from two goals down against Houston Dynamo to win by the same scoreline.
Elsewhere, another Rooney goal could not prevent D.C United from losing 2-1 to New York City FC, while Orlando City SC edged out New England Revolution by the same score after extra time.
USL Championship side New Mexico United beat FC Dallas 2-1, as Frater again appeared on on the scoresheet before, in sensational fashion, Saint Louis FC - another USL Championship team - scored a dramatic last-gasp winner against FC Cincinnati.
While Los Angeles FC are yet to play San Jose Earthquakes in their round of 16 game, we know that the winner will face the formidable Portland Timbers in the quarters. Fernandez has seven goals in four starts since joining from Necaxa in Mexico, and he will be a key player to look out for.
Orlando City SC are set to clash with New York City FC, who have lost their recognisable names of previous years in David Villa, Frank Lampard and Andrea Pirlo. However, former Manchester United winger Nani is on the books of Orlando, and with 8 goals in 13 games, he has made a promising start in America.
Atlanta United FC will host Saint Louis FC, and are considered the favourites heading into the match. Former Aston Villa goalkeeper Brad Guzan is among their ranks, as well as Paul Pogba's older brother, Florentin.
New Mexico United travel to Minnesota United FC for their quarter-final clash as the most likely of the two remaining USL Championship sides to progress. Former Arsenal goalkeeper Vino Mannone is currently on loan at Minnesota from Reading, with this match up the least intriguing of the round.