NEW YORK (AP) Serena Williams' loss to Roberta Vinci in the U.S. Open semifinals rates as one of the most significant surprises in tennis history.
Williams was seeded No. 1, ranked No. 1, already owns 21 major titles, including the past three at Flushing Meadows, and was seeking to complete a calendar-year Grand Slam, something last done by Steffi Graf in 1988.
Williams had won 33 consecutive matches at majors, including all 26 this season.
Vinci, a 32-year-old Italian, was unseeded, ranked 43rd, and had never made it past the quarterfinals at any Grand Slam tournament in 43 previous appearances.
Even Vinci called her 2-6, 6-4, 6-4 victory Friday ''a miracle.''
Some of the other big upsets in women's Grand Slam tennis matches over the past 25 years:
2012 French Open, first round, lost to 111th-ranked Virginie Razzano of France 4-6, 7-6 (5), 6-3. That was Williams' only first-round loss at any major tournament. Williams already had 13 Grand Slam titles, including in Paris a decade earlier, while Razzano only twice has even reached the fourth round in 57 majors.
1994 Wimbledon, first round, lost to 22nd-ranked Lori McNeil 7-5, 7-6 (5). Graf had won five of the preceding six Wimbledon titles, including three in a row, but became the first defending champion to lose in the first round at the All England Club.
1983 French Open, fourth round, lost to 33rd-ranked Kathleen Horvath 6-4, 0-6, 6-3. Navratilova had won two of the previous three majors and would go on to win the next six Grand Slam tournaments. The defeat to Horvath was the only loss for Navratilova in 84 matches that season. It was Horvath's first time into the fourth round at a major.
2009 U.S. Open, third round, lost to 70th-ranked Melanie Oudin 3-6, 6-4, 7-5. Sharapova already owned three Grand Slam titles by then, including in New York in 2006. Oudin was playing in her fourth major tournament.
2004 French Open, second round, lost to 86th-ranked Tathiana Garbin 7-5, 6-4. Henin was the defending champion and had won three of the previous four major tournaments. Garbin had only made one fourth-round run at a major.
Associated Press Writer Robbie Mendelson contributed to this report.