Getlin added that the Ducks are concerned the injury is a torn ACL.
A separate report from Comcast Sports Net characterized the injury as severe and said that Ekpre-Olomu will miss the rest of the season.
Oregon coach Mark Helfrich confirmed on Thursday that Ekpre-Olomu will not participate in the upcoming College Football Playoff.
Over 13 games this season, Ekpre-Olomu has recorded 63 tackles, two interceptions and nine pass breakups while helping the Ducks rank third in the Pac-12 in passing efficiency defense.
The No. 2 Ducks (12-1) are slated to face No. 3 Florida State (13-0) in the Rose Bowl, one of two semifinals for playoff. Ekpre-Olomu was expected to line up against Rashad Greene, the Seminoles' leading receiver.
In his latest 2015 mock draft, SI.com's Chris Burke projects Ekpre-Olomu to be selected with the No. 21 overall pick.