The Colts open the regular season against the Broncos on Sunday, once again pitting Manning against his former team.
It also is a chance for Wayne to go against Manning. Wayne had more than 10,000 receiving yards on passes from Manning over their 11 seasons together.
"He's my brother," Wayne said to USA Today. "He's the enemy."
Wayne also said the same thing about Ed Reed, his former college teammate at the University of Miami. Reed is currently a free agent.
"I want to beat him every time," Wayne said. "Once the whistle blows, you're their enemy. When the fourth quarter comes and it's all zeroes on there, now we can laugh and talk about whatever it is.
- Scooby Axson