2026 College Basketball National Championship Odds: Duke's Odds Drop After Surviving Upset

The Duke Blue Devils entered the 2026 NCAA Tournament as the favorite to win it all, but that quickly changed after the Blue Devils fell behind by double digits in the first half in a comeback win over Siena.

A 27.5-point favorite, Duke won by just six points against the Siena Saints, and oddsmakers have dropped the Blue Devils' odds to win the national championship as a result. After opening as the favorite at +330, Duke has fallen behind both Arizona (+360) and Michigan (+380) in the odds at the best betting sites.

Duke has a tough bracket with UConn, Michigan State, St. John's and Louisville all lurking as potential contenders to make the regional final. The Blue Devils don't have star guard Caleb Foster, and that could be part of the reason the team got off to such a slow start on Thursday afternoon.

Still, Duke is firmly in the picture to win March Madness, even if oddsmakers now view Michigan and Arizona as better teams. Duke will have a chance to prove that it is the favorite in the second round on Saturday against the TCU Horned Frogs, who beat Ohio State in the opening game of the first round.

Only four teams have shorter than 10/1 odds at this point in the tournament and just eight teams are shorter than 20/1. Surpsingly enough, UConn (+3500) and Michigan State (+4000) still remain further out in the odds even though Duke was tested in the first round.

Latest Odds to Win March Madness

Odds via FanDuel Sportsbook

Arizona: +360
Michigan: +380
Duke: +500
Florida: +700
Houston: +1100
Iowa State: +1400
Illinois: +1700
Purdue: +1900
Connecticut: +3500
Michigan State: +4000
Arkansas: +4000
Gonzaga: +4500
Virginia: +7500
St. John's: +8000
Vanderbilt: +8000
Kansas: +10000
Alabama: +12500
Nebraska: +12500
Tennessee: +12500
Louisville: +15000
UCLA: +17500
Texas Tech: +17500
BYU: +30000
Kentucky: +35000
Saint Mary's: +40000
Iowa: +40000
Miami: +60000
TCU: +60000
North Carolina: +70000
Clemson: +70000
Georgia: +75000
Villanova: +100000
Utah State: +100000
Saint Louis: +100000
UCF: +100000
Missouri: +100000
Santa Clara: +100000
Texas A&M: +100000
Texas: +100000
Miami (OH): +100000
VCU: +100000
Northern Iowa: +100000
High Point: +100000
Akron: +100000
McNeese: +100000
California Baptist: +100000
Hawai'i: +100000
Hofstra: +100000
North Dakota State: +100000
Kennesaw State: +100000
Wright State: +100000
Pennsylvania: +100000
Furman: +100000
Queen's University: +100000
Tennessee State: +100000
Idaho: +100000
Long Island University: +100000
Howard: +100000
Prairie View A&M: +100000

Odds refresh periodically and are subject to change.

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