Cardinals vs. Brewers Prediction, Odds, Probable Pitchers, Prop Bets for Tuesday, May 26

Kyle Harrison and the Milwaukee Brewers are big home favorites against the St. Louis Cardinals on Tuesday night. | Benny Sieu-Imagn Images

The Milwaukee Brewers widened their lead in the NL Central on Monday night when they cruised past the St. Louis Cardinals by a final score of 5-1. The Brewers are now 2.5 games clear of the Cardinals, but will face them again tonight in the second game of a three-game set.

Let's dive into the odds and my best bets for tonight's matchup.

Cardinals vs. Brewers Odds, Run Line, and Total

Odds via BetMGM Sportsbook

Run Line

• Cardinals +1.5 (-135)
• Brewers -1.5 (+110)

Moneyline

• Cardinals +155
• Brewers -190

Total

• OVER 8 (-110)
• UNDER 8 (-110)

Cardinals vs. Brewers Probable Pitchers

• St. Louis: Michael McGreevy, RHP (3-3, 2.40 ERA)
• Milwaukee: Kyle Harrison, LHP (5-1, 1.77 ERA)

Cardinals vs. Brewers How to Watch

• Date: Tuesday, May 26
• Time: 7:40 p.m. ET
• Venue: American Family Field
• How to Watch (TV): Brewers.TV, Cardinals.TV
• Cardinals record: 29-23
• Brewers record: 31-20

Cardinals vs. Brewers Best MLB Prop Bet

In today's edition of Betting $100 Every Day for a Year, I wrote about why I'm betting on Kyle Harrison to remain UNDER his strikeout total of 6.5:

The St. Louis Cardinals have struck out on just 17.6% of plate appearances against left-handed pitchers this season, the third-best mark amongst all teams. That could mean tonight is a great time to sell your stock on Kyle Harrison's strikeout numbers. Harrison is averaging 11.6 strikeouts per nine innings this season, which is two strikeouts more than his average rate in 2025. That tells me he's going to see some regression in that area sooner rather than later, and tonight is as good a night as any for that number to fall.

Cardinals vs. Brewers Prediction and Pick

Michael McGreevy may have an ERA of 2.40, but his 4.01 FIP (Field Independent Pitching) tells me that he may struggle in his upcoming start. He allowed 10 hits and three earned runs against the Pirates in his last outing, and now he has to face a Brewers lineup that's seventh in wRC+ with an OPS of .726 when facing right-handed pitchers this season.

I also have some concerns with the Cardinals' bullpen. They have a bullpen ERA of 4.41, which ranks 22nd in the Majors. That means even if McGreevy can overperform in another start, the Cardinals' bullpen may let them down late in the game.

I'll back the Brewers as sizable home favorites.

Pick: Brewers -190 via BetMGM

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