College Football Week 1 Opening Odds for Every Game (LSU Favored Over Clemson, Ole Miss Favored vs. Louisville)

College Football returned with an exciting slate of games in Week 0, but it was just an appetizer for what is ahead in Week 1 of the 2026 season.

Since the 2026 NFL season doesn’t start until the following week, there will be major College Football games on Thursday, Friday, Saturday, Sunday and Monday – an amazing way to get back into the football season. For bettors, there are a ton of options to consider, even with many of the top-25 teams playing games that they are heavily favored in.

After all, both Memphis and North Carolina pulled off upsets in Week 0, and we could see a few more teams pick up surprising Week 1 wins.

There are a few bigger games to watch in this slate, a few of which won’t be on Saturday:

Baylor vs. Auburn (Saturday)
Clemson vs. LSU (Saturday)
Wisconsin vs. Notre Dame (Sunday)
Louisville vs. Ole Miss (Sunday)
SMU vs. Florida State (Monday)

So, without further ado, here’s a look at every game in the FBS for Week 1 and which team is favored in that matchup.

College Football Week 1 Odds

Odds via DraftKings Sportsbook

Thursday, Sept. 3

UMass vs. Rutgers

Spread: Rutgers -29.5 (-110) | UMass +29.5 (-110)
Total: 52.5 (Over -112/Under -108)

Akron vs. Wake Forest

Spread: Wake Forest -23.5 (-115) | Akron +23.5 (-105)
Total: 48.5 (Over -105/Under -115)

West Georgia vs. Kennesaw State

Spread: Kennesaw State -22.5 (-105) | West Georgia +22.5 (-115)
Total: 51.5 (Over -112/Under -108)

Albany (NY) vs. Buffalo

Spread: Buffalo -24.5 (-108) | Albany NY +24.5 (-112)
Total: 48.5 (Over -108/Under -112)

Merrimack vs. Delaware

Spread: Delaware -28.5 (-112) | Merrimack +28.5 (-108)
Total: 55.5 (Over -110/Under -110)

Bethune-Cookman vs. UCF

Spread: UCF -42.5 (-110) | Bethune-Cookman +42.5 (-110)
Total: 59.5 (Over -112/Under -108)

Colorado vs. Georgia Tech

Spread: Georgia Tech -6.5 (-110) | Colorado +6.5 (-110)
Total: 50.5 (Over -115/Under -105)

Arkansas-Pine Bluff vs. No. 25 Missouri

Spread: Missouri -54.5 (-112) | Arkansas-Pine Bluff +54.5 (-108)
Total: 60.5 (Over -108/Under -112)

Idaho vs. No. 21 Utah

Spread: Utah -33.5 (-112) | Idaho +33.5 (-108)
Total: 56.5 (Over -108/Under -112)

Eastern Illinois vs. Minnesota

Spread: Eastern Illinois +43.5 (-112) | Minnesota -43.5 (-108)
Total: 51.5 (Over -110/Under -110)

UAB vs. Illinois

Spread: UAB +28.5 (-112) | Illinois -28.5 (-108)
Total: 55.5 (Over -115/Under -105)

Friday, Sept. 4

San Jose State vs. Eastern Michigan

Spread: Eastern Michigan -3.5 (-112) | San Jose State +3.5 (-108)
Total: 54.5 (Over -115/Under -105)

North Carolina A&T vs. Georgia State

Spread: Georgia State -27.5 (-110) | North Carolina A&T +27.5 (-110)
Total: 63.5 (Over -108/Under -112)

Indiana State vs. Purdue

Spread: Purdue -34.5 (-110) | Indiana State +34.5 (-110)
Total: 56.5 (Over -110/Under -110)

LIU vs. Kansas

Spread: Kansas -38.5 (-110) | LIU +38.5 (-110)
Total: 53.5 (Over -112/Under -108)

Toledo vs. Michigan State

Spread: Michigan State -10 (-110) | Toledo +10 (-110)
Total: 49.5 (Over -110/Under -110)

UTEP vs. No. 10 Oklahoma

Spread: Oklahoma -41.5 (-118) | UTEP +41.5 (-102)
Total: 50.5 (Over -108/Under -112)

No. 7 Miami FL vs. Stanford

Spread: Miami FL -23.5 (-112) | Stanford +23.5 (-108)
Total: 47.5 (Over -112/Under -108)

Fresno State vs. No. 15 USC

Spread: USC -23.5 (-108) | Fresno State +23.5 (-112)
Total: 51.5 (Over -108/Under -112)

Saturday, Sept. 5

Ball State vs. No. 1 Ohio State

Spread: Ohio State -49.5 (-108) | Ball State +49.5 (-112)
Total: 57.5 (Over -105/Under -115)

Tarleton State vs. Bowling Green

Spread: Bowling Green -2.5 (-112) | Tarleton State +2.5 (-108)
Total: 47.5 (Over -110/Under -110)

East Carolina vs. No. 13 Alabama

Spread: Alabama -28.5 (-108) | East Carolina +28.5 (-112)
Total: 53.5 (Over -115/Under -105)

Bryant vs. Army

Spread: Bryant +36.5 (-112) | Army -36.5 (-108)
Total: 51.5 (Over -108/Under -112)

Youngstown State vs. Kentucky

Spread: Youngstown State +23.5 (-115) | Kentucky -23.5 (-105)
Total: 62.5 (Over -110/Under -110)

SE Missouri vs. Iowa State

Spread: SE Missouri +29.5 (-112) | Iowa State -29.5 (-108)
Total: 53.5 (Over -105/Under -115)

Marshall vs. No. 18 Penn State

Spread: Penn State -24.5 (-110) | Marshall +24.5 (-110)
Total: 54.5 (Over -110/Under -110)

North Texas vs. No. 6 Indiana

Spread: Indiana -40.5 (-112) | North Texas +40.5 (-108)
Total: 57.5 (Over -115/Under -105)

Coastal Carolina vs. West Virginia

Spread: West Virginia -21.5 (-110) | Coastal Carolina +21.5 (-110)
Total: 54.5 (Over -110/Under -110)

New Hampshire vs. Syracuse

Spread: Syracuse -31.5 (-110) | New Hampshire +31.5 (-110)
Total: 54.5 (Over -110/Under -110)

Rhode Island vs. Temple

Spread: Temple -10.5 (-108) | Rhode Island +10.5 (-112)
Total: 51.5 (Over -110/Under -110)

Boise State vs. No. 2 Oregon

Spread: Oregon -24.5 (-108) | Boise State +24.5 (-112)
Total: 51.5 (Over -118/Under -102)

Baylor vs. Auburn

Spread: Auburn -7 (-112) | Baylor +7 (-108)
Total: 59.5 (Over -102/Under -118)

Oregon State vs. Houston

Spread: Houston -20.5 (-115) | Oregon State +20.5 (-105)
Total: 51.5 (Over -105/Under -115)

Tennessee State vs. No. 3 Georgia

Spread: Georgia -47.5 (-102) | Tennessee State +47.5 (-118)
Total: 55.5 (Over -115/Under -105)

Furman vs. No. 20 Tennessee

Spread: Tennessee -46.5 (-110) | Furman +46.5 (-110)
Total: 66.5 (Over -105/Under -115)

Boston College vs. Cincinnati

Spread: Cincinnati -7.5 (-110) | Boston College +7.5 (-110)
Total: 51.5 (Over -110/Under -110)

Tulane vs. Duke

Spread: Duke -9.5 (-102) | Tulane +9.5 (-118)
Total: 50.5 (Over -115/Under -105)

Northern Illinois vs. No. 22 Iowa

Spread: Iowa -31.5 (-110) | Northern Illinois +31.5 (-110)
Total: 45.5 (Over -118/Under -102)

Florida Atlantic vs. Florida

Spread: Florida -27.5 (-105) | Florida Atlantic +27.5 (-115)
Total: 59.5 (Over -112/Under -108)

Ohio vs. Nebraska

Spread: Nebraska -23.5 (-110) | Ohio +23.5 (-110)
Total: 49.5 (Over -110/Under -110)

Western Michigan vs. No. 15 Michigan

Spread: Michigan -27.5 (-110) | Western Michigan +27.5 (-110)
Total: 48.5 (Over -110/Under -110)

Duquesne vs. Air Force

Spread: Air Force -30.5 (-108) | Duquesne +30.5 (-112)
Total: 58.5 (Over -105/Under -115)

Maine vs. Appalachian State

Spread: Appalachian State -18.5 (-112) | Maine +18.5 (-108)
Total: 53.5 (Over -108/Under -112)

North Alabama vs. Arkansas

Spread: Arkansas -40.5 (-108) | North Alabama +40.5 (-112)
Total: 63.5 (Over -105/Under -115)

Kent State vs. South Carolina

Spread: South Carolina -35.5 (-110) | Kent State +35.5 (-110)
Total: 53.0 (Over -110/Under -110)

FIU vs. South Florida

Spread: South Florida -13.5 (-110) | FIU +13.5 (-110)
Total: 53.5 (Over -115/Under -105)

Missouri State vs. Texas A&M

Spread: Texas A&M -41.5 (-102) | Missouri State +41.5 (-118)
Total: 52.5 (Over -110/Under -110)

ULM vs. Mississippi State

Spread: Mississippi State -28.5 (-110) | ULM +28.5 (-110)
Total: 56.5 (Over -105/Under -115)

Miami (OH) vs. Pittsburgh

Spread: Pittsburgh -19.5 (-115) | Lafayette +19.5 (-115)
Total: 58.5 (Over -110/Under -110)

Lafayette vs. UConn

Spread: UConn -16.5 (-110) | Miami (OH) +16.5 (-110)
Total: 47.5 (Over -110/Under -110)

Austin Peay vs. Vanderbilt

Spread: Vanderbilt -30.5 (-112) | Austin Peay +30.5 (-108)
Total: 61.5 (Over -108/Under -112)

Norfolk State vs. Old Dominion

Spread: Old Dominion -41.5 (-110) | Norfolk State +41.5 (-110)
Total: 55.5 (Over -105/Under -115)

Clemson vs. No. 11 LSU

Spread: LSU -10.5 (-110) | Clemson +10.5 (-110)
Total: 51.5 (Over -110/Under -110)

Texas State vs. No. 5 Texas

Spread: Texas -30.5 (-105) | Texas State +30.5 (-115)
Total: 59.5 (Over -112/Under -108)

Abilene Christian vs. No. 12 Texas Tech

Spread: Texas Tech -42.5 (-112) | Abilene Christian +42.5 (-108)
Total: 59.5 (Over -105/Under -115)

Utah Tech vs. No. 14 BYU

Spread: BYU -47.5 (-112) | Utah Tech +47.5 (-108)
Total: 54.5 (Over -105/Under -115)

Liberty vs. James Madison

Spread: James Madison -6.0 (-110) | Liberty +6.0 (-110)
Total: 52.5 (Over -110/Under -110)

Oklahoma State vs. Tulsa

Spread: Oklahoma State -14 (-110) | Tulsa +14 (-110)
Total: 60.5 (Over -108/Under -112)

Central Michigan vs. New Mexico

Spread: New Mexico -10.5 (-108) | Central Michigan +10.5 (-112)
Total: 46.5 (Over -115/Under -105)

Wyoming vs. Colorado State

Spread: Colorado State 3.5 (+100) | Wyoming +3.5 (-120)
Total: 47.5 (Over -112/Under -108)

Idaho State vs. Utah State

Spread: Utah State -12.5 (-110) | Idaho State +12.5 (-110)
Total: 63.5 (Over -110/Under -110)

Morgan State vs. Arizona State

Spread: Arizona State -41.5 (-110) | Morgan State +41.5 (-110)
Total: 52.5 (Over -112/Under -108)

UCLA vs. California

Spread: California +1.5 (-108) | UCLA -1.5 (-112)
Total: 53.5 (Over -112/Under -108)

Western Kentucky vs. Nevada

Spread: Western Kentucky -2.5 (-112) | Nevada +2.5 (-108)
Total: 52.5 (Over -112/Under -108)

Arkansas State vs. Memphis

Spread: Memphis -8.5 (-112) | Arkansas State +8.5 (-108)
Total: 55.5 (Over -105/Under -115)

Sam Houston vs. Troy

Spread: Troy -16.5 (-115) | Sam Houston +16.5 (-105)
Total: 53.5 (Over -105/Under -115)

Northern Arizona vs. Arizona

Spread: Northern Arizona +31.5 (-112) | Arizona -31.5 (-108)
Total: 56.5 (Over -108/Under -112)

Portland State vs. San Diego State

Spread: San Diego State -40.5 (-110) | Portland State +40.5 (-110)
Total: 57.5 (Over -105/Under -115)

UNLV vs. Hawaii

Spread: UNLV -3 (-112) | Hawaii +2.5 (-108)
Total: 58.5 (Over -110/Under -110)

Sunday, Sept. 6

Washington State vs. No. 17 Washington

Spread: Washington State +23.5 (-108) | Washington -23.5 (-112)
Total: 50.5 (Over -110/Under -110)

Wisconsin vs. No. 4 Notre Dame

Spread: Wisconsin +20.5 (-108) | Notre Dame -20.5 (-112)
Total: 47.5 (Over -110/Under -110)

No. 24 Louisville vs. No. 9 Ole Miss

Spread: Louisville +6.5 (-105) | Ole Miss -6.5 (-115)
Total: 55.5 (Over -108/Under -112)

Monday, Sept. 7

No. 19 SMU vs. Florida State

Spread: SMU -2.5 (-115) | Florida State +2.5 (-105)
Total: 52.5 (Over -112/Under -108)

Odds refresh periodically and are subject to change.

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