NFL Straight-Up Moneyline Picks for Every Game in Week 5

Iain MacMillan | Oct 1, 2025

The Sports Illustrated team breaks down their picks to win all 16 games in Week 5 of the 2025 NFL season. / Sports Illustrated

We're approaching quarter of the way through the 2025 NFL season. There are now four members of the SI panel who are sitting with a profitable record with their picks, including Conor Orr, who sits in first place at 44-19-1 for +8.09 units.

The team has their picks locked in for Week 5, so let's take a look at them.

Week 4 Results

• Clare Brennan, Associate Editor 8-7-1 (-3.50 units)
• Mitch Goldich, Senior Editor 9-6-1 (-1.20 units)
• Gilberto Manzano, NFL Staff Writer 12-3-1 (+3.93 units)
• Conor Orr, Senior Writer 9-6-1 (-2.01 units)
• John Pluym, NFL Managing Editor 6-9-1 (-6.40 units)
• Matt Verderame, NFL Staff Writer 9-6-1 (-1.26 units)
• Iain MacMillan, Senior Editor, Betting 8-7-1 (-2.64 units)
• Peter Dewey, Associate Managing Editor, Betting 8-7-1 (-3.44 units)

Season-to-Date Results

• Clare Brennan, Associate Editor 43-20-1 (+3.15 units)
• Mitch Goldich, Senior Editor 42-21-1 (+2.18 units)
• Gilberto Manzano, NFL Staff Writer 38-25-1 (-4.39 units)
• Conor Orr, Senior Writer 44-19-1 (+8.09 units)
• John Pluym, NFL Managing Editor 39-24-1 (-4.1 units)
• Matt Verderame, NFL Staff Writer 44-19-1 (+4.59 units)
• Iain MacMillan, Senior Editor, Betting 35-28-1 (-8.66 units)
• Peter Dewey, Associate Managing Editor, Betting 39-24-1 (-5.19 units)

NFL Week 5 Picks

All odds listed are via DraftKings Sportsbook

NFL Week 5 moneyline picks / Sports Illustrated

49ers (+245) vs. Rams (-305)

• Clare Brennan: Rams
• Mitch Goldich: Rams
• Gilberto Manzano: Rams
• Conor Orr: Rams
• John Pluym: Rams
• Matt Verderame: Rams
• Iain MacMillan: Rams
• Peter Dewey: Rams

Vikings (-218) vs. Browns (+180)

• Clare Brennan: Vikings
• Mitch Goldich: Vikings
• Gilberto Manzano: Browns
• Conor Orr: Vikings
• John Pluym: Vikings
• Matt Verderame: Vikings
• Iain MacMillan: Browns
• Peter Dewey: Vikings

Broncos (+164) vs. Eagles (-198)

• Clare Brennan: Eagles
• Mitch Goldich: Eagles
• Gilberto Manzano: Eagles
• Conor Orr: Broncos
• John Pluym: Eagles
• Matt Verderame: Eagles
• Iain MacMillan: Broncos
• Peter Dewey: Eagles

Texans (-122) vs. Ravens (+102)

• Clare Brennan: Ravens
• Mitch Goldich: Texans
• Gilberto Manzano: Texans
• Conor Orr: Ravens
• John Pluym: Texans
• Matt Verderame: Texans
• Iain MacMillan: Ravens
• Peter Dewey: Texans

Giants (+105) vs. Saints (-125)

• Clare Brennan: Giants
• Mitch Goldich: Giants
• Gilberto Manzano: Giants
• Conor Orr: Saints
• John Pluym: Giants
• Matt Verderame: Giants
• Iain MacMillan: Saints
• Peter Dewey: Giants

Cowboys (-142) vs. Jets (+120)

• Clare Brennan: Cowboys
• Mitch Goldich: Cowboys
• Gilberto Manzano: Cowboys
• Conor Orr: Cowboys
• John Pluym: Cowboys
• Matt Verderame: Cowboys
• Iain MacMillan: Jets
• Peter Dewey: Cowboys

Raiders (+260) vs. Colts (-325)

• Clare Brennan: Colts
• Mitch Goldich: Colts
• Gilberto Manzano: Colts
• Conor Orr: Colts
• John Pluym: Colts
• Matt Verderame: Colts
• Iain MacMillan: Colts
• Peter Dewey: Colts

Dolphins (-120) vs. Panthers (+100)

• Clare Brennan: Panthers
• Mitch Goldich: Dolphins
• Gilberto Manzano: Dolphins
• Conor Orr: Dolphins
• John Pluym: Panthers
• Matt Verderame: Panthers
• Iain MacMillan: Dolphins
• Peter Dewey: Dolphins

Buccaneers (+140) vs. Seahawks (-166)

• Clare Brennan: Seahawks
• Mitch Goldich: Seahawks
• Gilberto Manzano: Buccaneers
• Conor Orr: Seahawks
• John Pluym: Buccaneers
• Matt Verderame: Buccaneers
• Iain MacMillan: Seahawks
• Peter Dewey: Buccaneers

Titans (+300) vs. Cardinals (-380)

• Clare Brennan: Cardinals
• Mitch Goldich: Cardinals
• Gilberto Manzano: Cardinals
• Conor Orr: Cardinals
• John Pluym: Cardinals
• Matt Verderame: Cardinals
• Iain MacMillan: Cardinals
• Peter Dewey: Cardinals

Commanders (+130) vs. Chargers (-155)

• Clare Brennan: Chargers
• Mitch Goldich: Chargers
• Gilberto Manzano: Chargers
• Conor Orr: Chargers
• John Pluym: Chargers
• Matt Verderame: Commanders
• Iain MacMillan: Chargers
• Peter Dewey: Chargers

Lions (-535) vs. Bengals (+400)

• Clare Brennan: Lions
• Mitch Goldich: Lions
• Gilberto Manzano: Lions
• Conor Orr: Lions
• John Pluym: Lions
• Matt Verderame: Lions
• Iain MacMillan: Lions
• Peter Dewey: Lions

Patriots (+300) vs. Bills (-380)

• Clare Brennan: Bills
• Mitch Goldich: Bills
• Gilberto Manzano: Bills
• Conor Orr: Bills
• John Pluym: Bills
• Matt Verderame: Bills
• Iain MacMillan: Patriots
• Peter Dewey: Bills

Chiefs (-185) vs. Jaguars (+154)

• Clare Brennan: Chiefs
• Mitch Goldich: Chiefs
• Gilberto Manzano: Chiefs
• Conor Orr: Chiefs
• John Pluym: Chiefs
• Matt Verderame: Chiefs
• Iain MacMillan: Chiefs
• Peter Dewey: Chiefs

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