NFL Straight-Up Moneyline Picks for Every Game in Week 6

We're now officially through the quarter-mark of the 2026 NFL regular season, and Week 5 was a rough outing for almost the entire SI team. Gilberto Manzano was the only member of the roundtable to post a profitable Week 5 record, going 10-4-1 for a profit of +2.37 units.

We move on to Week 6 and with four teams on BYE this week, we have just 14 games to watch and bet on.

Let's take a look at the results so far this season, and then we'll dive into everyone's picks for Week 6.

NFL Week 5 Results

Albert Breer, Senior Writer: 8-6-1 (-0.89 units)
Eva Geitheim, NFL Writer: 8-6-1 (-0.49 units)
Mitch Goldich, Senior Editor: 6-8-1 (-4.33 units)
Mike Kadlick, NFL Senior News Writer: 6-8-1 (-4.67 units)
Gilberto Manzano, NFL Staff Writer: 10-4-1 (+2.37 units)
Conor Orr, Senior Writer: 7-7-1 (-3.90 units)
John Pluym, NFL Managing Editor: 7-7-1 (-3.90 units)
Matt Verderame, NFL Staff Writer: 7-7-1 (-3.77 units)
Iain MacMillan, Senior Editor, Betting: 7-7-1 (-3.37 units)
Peter Dewey, Associate Managing Editor, Betting: 8-6-1 (-1.72 units)

Season-to-Date Results

Albert Breer, Senior Writer: 44-34-1 (-11.01 units)
Eva Geitheim, NFL Writer: 46-32-1 (-3.76 units)
Mitch Goldich, Senior Editor: 42-35-1 (-15.63 units)
Mike Kadlick, NFL Senior News Writer: 44-34-1 (-9.93 units)
Gilberto Manzano, NFL Staff Writer: 43-35-1 (-8.14 units)
Conor Orr, Senior Writer: 45-33-1 (-5.61 units)
John Pluym, NFL Managing Editor: 44-34-1 (-12.35 units)
Matt Verderame, NFL Staff Writer: 47-31-1 (-6.32 units)
Iain MacMillan, Senior Editor, Betting: 46-32-1 (-1.76 units)
Peter Dewey, Associate Managing Editor, Betting: 45-33-1 (-8.79 units)

NFL Week 6 Picks

All odds listed are via DraftKings Sportsbook

Seahawks (-148) vs. Broncos (+124)

Albert Breer:
Eva Geitheim: Seahawks
Mitch Goldich:
Mike Kadlick: Seahawks
Gilberto Manzano: Seahawks
Conor Orr: Seahawks
John Pluym: Seahawks
Matt Verderame: Seahawks
Iain MacMillan: Seahawks
Peter Dewey: Seahawks

Texans (+120) vs. Jaguars (-142)

Albert Breer:
Eva Geitheim: Jaguars
Mitch Goldich:
Mike Kadlick: Jaguars
Gilberto Manzano: Jaguars
Conor Orr: Texans
John Pluym: Jaguars
Matt Verderame: Jaguars
Iain MacMillan: Texans
Peter Dewey: Texans

Bears (-162) vs. Falcons (+136)

Albert Breer:
Eva Geitheim: Falcons
Mitch Goldich:
Mike Kadlick: Bears
Gilberto Manzano: Bears
Conor Orr: Bears
John Pluym: Bears
Matt Verderame: Bears
Iain MacMillan: Bears
Peter Dewey: Bears

Ravens (-265) vs. Browns (+215)

Albert Breer:
Eva Geitheim: Ravens
Mitch Goldich:
Mike Kadlick: Ravens
Gilberto Manzano: Ravens
Conor Orr: Ravens
John Pluym: Ravens
Matt Verderame: Ravens
Iain MacMillan: Ravens
Peter Dewey: Ravens

Titans (+260) vs. Colts (-325)

Albert Breer:
Eva Geitheim: Colts
Mitch Goldich:
Mike Kadlick: Titans
Gilberto Manzano: Titans
Conor Orr: Colts
John Pluym: Colts
Matt Verderame: Colts
Iain MacMillan: Titans
Peter Dewey: Colts

Jets (+270) vs. Patriots (-340)

Albert Breer:
Eva Geitheim: Patriots
Mitch Goldich:
Mike Kadlick: Patriots
Gilberto Manzano: Patriots
Conor Orr: Patriots
John Pluym: Patriots
Matt Verderame: Patriots
Iain MacMillan: Patriots
Peter Dewey: Patriots

Saints (-118) vs. Giants (-102)

Albert Breer:
Eva Geitheim:
Mitch Goldich:
Mike Kadlick: Saints
Gilberto Manzano: Saints
Conor Orr: Saints
John Pluym: Giants
Matt Verderame: Saints
Iain MacMillan: Saints
Peter Dewey: Giants

Panthers (-110) vs. Eagles (-110)

Albert Breer:
Eva Geitheim: Panthers
Mitch Goldich:
Mike Kadlick: Panthers
Gilberto Manzano: Panthers
Conor Orr: Eagles
John Pluym: Eagles
Matt Verderame: Eagles
Iain MacMillan: Panthers
Peter Dewey: Panthers

Steelers (-142) vs. Buccaneers (+120)

Albert Breer:
Eva Geitheim: Steelers
Mitch Goldich:
Mike Kadlick: Buccaneers
Gilberto Manzano: Steelers
Conor Orr: Buccaneers
John Pluym: Steelers
Matt Verderame: Steelers
Iain MacMillan: Buccaneers
Peter Dewey: Steelers

Cardinals (+600) vs. Rams (-900)

Albert Breer:
Eva Geitheim: Rams
Mitch Goldich:
Mike Kadlick: Rams
Gilberto Manzano: Rams
Conor Orr: Rams
John Pluym: Rams
Matt Verderame: Rams
Iain MacMillan: Rams
Peter Dewey: Rams

Chargers (+380) vs. Chiefs (-500)

Albert Breer:
Eva Geitheim: Chiefs
Mitch Goldich:
Mike Kadlick: Chiefs
Gilberto Manzano: Chiefs
Conor Orr: Chiefs
John Pluym: Chiefs
Matt Verderame: Chiefs
Iain MacMillan: Chiefs
Peter Dewey: Chiefs

Bills (-258) vs. Raiders (+210)

Albert Breer:
Eva Geitheim: Bills
Mitch Goldich:
Mike Kadlick: Bills
Gilberto Manzano: Bills
Conor Orr: Raiders
John Pluym: Bills
Matt Verderame: Bills
Iain MacMillan: Bills
Peter Dewey: Bills

Cowboys (+102) vs. Packers (-122)

Albert Breer:
Eva Geitheim: Packers
Mitch Goldich:
Mike Kadlick: Packers
Gilberto Manzano: Packers
Conor Orr: Packers
John Pluym: Packers
Matt Verderame: Packers
Iain MacMillan: Packers
Peter Dewey: Packers

Commanders (+330) vs. 49ers (-425)

Albert Breer:
Eva Geitheim: 49ers
Mitch Goldich:
Mike Kadlick: 49ers
Gilberto Manzano: 49ers
Conor Orr: 49ers
John Pluym: 49ers
Matt Verderame: 49ers
Iain MacMillan: 49ers
Peter Dewey: 49ers

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