Super Bowl Odds: 49ers Jump to Favorite; Bills Rising After Upset Win vs. Rams in Week 5

It only took five weeks for there to be a new favorite to win the Super Bowl.

Brock Purdy and the San Francisco 49ers are 5-0 and have a two-game lead in the NFC West, which has led oddsmakers to push them up to +700 to win the Super Bowl, tied with the preseason favorite – the Los Angeles Rams.

Los Angeles is off to a 2-3 start in 2026, losing to the Buffalo Bills in overtime on Monday night. While the Rams haven’t been fully healthy (Myles Garrett has played in just one game and Puka Nacua has played in just three games), they’ve lost to multiple Super Bowl contenders in San Francisco, Buffalo and Denver over the first five weeks.

Following Week 5, there are five teams shorter than 10/1 to win the Super Bowl: San Francisco, Los Angeles, Buffalo, Baltimore and Kansas City. The Ravens (4-1) have been surging in this market after beating the Atlanta Falcons on Sunday night without starting quarterback Lamar Jackson (ankle).

If Jackson returns in Week 6, the Ravens have a chance to stake their claim as the best team in the AFC.

Entering the regular season, nearly half the league was set at 30/1 or shorter to win the Super Bowl, and there is still a formidable chasing pack behind these top-five teams. In fact, 12 total teams have 20/1 odds or better to win Super Bowl LXI, including the defending champion Seattle Seahawks (+1100) and the two teams that played in the AFC title game last season (Denver and New England), who are both 20/1.

Super Bowl Odds for 2026 NFL Season

Odds via DraftKings Sportsbook

San Francisco 49ers: +700
Los Angeles Rams: +700
Buffalo Bills: +800
Baltimore Ravens: +800
Kansas City Chiefs: +950
Seattle Seahawks: +1100
Jacksonville Jaguars: +1200
Cincinnati Bengals: +1900
New England Patriots: +2000
Minnesota Vikings: +2000
Denver Broncos: +2000
Chicago Bears: +2000
Detroit Lions: +2600
Dallas Cowboys: +3000
Philadelphia Eagles: +4000
Houston Texans: +4500
Green Bay Packers: +4500
Atlanta Falcons: +6000
Carolina Panthers: +7400
Indianapolis Colts: +8000
Pittsburgh Steelers: +9000
Las Vegas Raiders: +9000
Washington Commanders: +10000
Tampa Bay Buccaneers: +12500
New York Giants: +12500
New Orleans Saints: +15000
Los Angeles Chargers: +20000
Cleveland Browns: +25000
New York Jets: +30000
Arizona Cardinals: +50000
Tennessee Titans: +100000
Miami Dolphins: +100000

At this point in the season, the biggest question is whether or not bettors should trust the Rams as a top team in the league.

Even though Los Angeles is 2-3 this season, it was viewed as the No. 1

Heading into Monday night’s matchup with the Bills, multiple oddsmakers told Sports Illustrated that L.A. remained their top team despite a 2-2 start.

“For this particular game, on a neutral field, it would probably be priced as a pick 'em,”Ty Gour, Sports Trader at Fanatics Sportsbook, told Sports Illustrated. “And the reason for that being no Myles Garrett and possibly no Aaron Donald as well, that's just going to take a little bit away from the Rams' defense. However, fully healthy on a neutral field, and that includes Josh Allen as well, the Rams probably land about a 1- to 1.5-point favorite. We don't see much of a gap right now between the two teams, but still notable enough for us to declare the Rams as No. 1.”

It appears that sentiment has changed a little with the 49ers moving into the No. 1 spot in the Super Bowl odds after Week 5.

There’s a long way to go in the 2026 regular season, but the NFC West title is looking increasingly unlikely for Matthew Stafford and Co., as the 49ers have a three-game lead over them and a head-to-head victory in Australia that was considered a Rams home game.

Los Angeles still sits in the top 10 in the NFL in EPA/Play on offense and defense this season, but the team’s struggles against other Super Bowl contenders is a major concern when assessing its long-term viability in the futures market. I’d stay away from the Rams at this current Super Bowl price, especially since they may have to go on the road as a wild card team in the playoffs later on this season.

Odds refresh periodically and are subject to change.

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