It feels crass to look at the ending of a promising young player's season from a fantasy football perspective, but since this is a fantasy football column and that's what everyone did on Twitter anyway, let's go ahead.
Jamaal Charles is out for the year after planting his knee funny (and then crashing into the Lions' mascot, Roary). It's sad for him and sad to a lesser extent for fantasy owners of the Chiefs running back. It's the second major fantasy injury this season, after Peyton Manning, and dejected owners who have both can probably pack it in this season.
The guy to target this week is Thomas Jones, who has rushed 13 times for 43 yards this season. He has the most carries on the team this year, and the Chiefs can't be down by 30 every week, can they?
Another interesting option is Dexter McCluster, who's eligible at either wide receiver or running back depending on what league you're in. He's rushed 12 times this year and been targeted for 10 passes. He's too small to get a full workload, so he's not a great RB option, but if he continues to get a bunch of carries and targets he's a useful third or fourth wide receiver.
Neither guy is going to put up great numbers, certainly not as good as would have been expected from Charles. Here's the rest of the waiver pickups for Week 2.