Alejandro De Aza had two RBIs for Baltimore.
For the second time in three days, Orioles manager Buck Showalter used a minor league pitcher against an American League East opponent.
Zach Davies started instead of Wei-Yin Chen, who pitched a minor league game. Chen is scheduled to start against the Rays on opening day.
Davies allowed one run on five hits in 3 1-3 innings.
Matt Andriese trying for a spot on the injury-riddled Tampa Bay staff, gave up five runs on eight hits in three innings.
Joey Butler hit a three-run home run in the ninth inning to tie the score.
Orioles: SS J.J. Hardy is likely to start the season on the 15-day disabled list with a left shoulder strain. Hardy injured the shoulder when he collided with 2B Jonathan Schoop on Friday.
''It's pretty good news, all things considered,'' Showalter said. ''We're still optimistic. What's unoptimistic is something that might require surgery or be longer than the time frame that they're thinking.''
Everth Cabrera and Ryan Flaherty are the primary candidates to replace Hardy while he's out.
Rays: LHP Drew Smyly, who is out with shoulder tendinitis, will throw batting practice Wednesday and Saturday. After that, he'll go on a minor league rehab assignment. ... RHP Alex Cobb (forearm tendinitis) played catch for the second time since he was cleared to resume throwing. ... RHP Matt Moore (Tommy John surgery) and LHP Jake McGee (elbow surgery) are scheduled for bullpens on Tuesday.
Orioles: The 22 year-old Davies had a good time in his first start against major leaguers. ''There was a little bit of nerves at first, kind of what to expect, but made sure that I didn't get too nervous out there and made sure it didn't affect me while I was on the mound,'' Davies said.
Rays: In Andriese's first five starts, he allowed two earned runs on 14 hits in 16 1-3 innings. ''I wished I could have gone four or five or six,'' Andriese said. ''I would have loved to go out there and go six today with no runs. The results weren't there.''
Orioles: Reassigned C J.P. Arencibia to minor league camp. The Orioles have 36 in camp.
Rays: Reassigned RHPs Brandon Gomes, Jhan Marinez, Jim Miller, LHP Jordan Norberto, C Mayo Acosta and OFs Corey Brown and Joey Butler to minor league camp. Manager Kevin Cash says they will remain with the team for its final spring games.
Showalter said that Pat Connaughton, the Notre Dame basketball star who is also a pitcher in Baltimore's minor league system, would not report to the team any time soon.
''We're not going to pressure him, push him. We want, though, when he decides that it is done, the NBA ain't there, then his full attention comes to baseball instead of coming right to us and then wondering.''
Orioles: RHP Kevin Gausman, who is still in contention for the fifth spot in the rotation starts against a Tampa Bay split squad on Tuesday. LHP Everett Teaford starts for the second time in four days against the Orioles in Sarasota.
Rays: Veteran RHP Jim Miller starts for Tampa Bay against Boston LHP Wade Miley in Port Charlotte. Cash will attend the home game.