Loney was out with a broken finger since sustaining the injury sliding headfirst into third base on May 24. He played two rehab games before his return Friday night.
''Ready to go,'' Loney said.
The Rays hope Loney will boost an offense that lacked a single baserunner for the first five innings in each of the first three of a four-game sweep at the hands of Cleveland this week.
Loney was batting .275 with two home runs and 11 RBIs this year.
Tampa Bay optioned right-hander Preston Guilmet to Triple-A Durham after Thursday's loss.