The Astros jumped to an early 1-0 lead with a homer from Yuli Gurriel in the second inning. Houston doubled its lead in the fifth inning after Carlos Correa smoked a grounder down the third-base line to bring Gurriel around to score.
The Nationals' comeback started with a solo home run from Anthony Rendon in the seventh inning. Howie Kendrick then took Will Harris deep for a two-run homer to give the Nationals a 3-2 lead. Juan Soto's RBI-single in the eighth inning and Adam Eaton's two-run single in the ninth inning gave Washington cushion.
Washington's Game 7 win capped the first World Series in baseball history in which visiting teams won all seven games.
In the locker room following the game, the Nationals went wild.