TNT reported Randle has a broken leg.
The seventh overall pick out of Kentucky had his right leg immobilized as he left the court, casting a pall over the Lakers' season opener against the Houston Rockets.
The 19-year-old Randle was injured when he collided with two Houston players under the Lakers' basket midway through the final period. He was in obvious pain as the Lakers' medical staff tended to him, eventually immobilizing his leg while Kobe Bryant gripped his hand in support.
Randle was the SEC's freshman of the year while helping the Wildcats to the NCAA championship game last season.