Gibson clutched his ankle and grimaced in pain before he was helped off the court. There was no immediate word on his condition from the team.
The 6-foot-9 forward was averaging 12.9 points and 5.9 rebounds going into the game.
Chicago was also without starting guard Kirk Hinrich, who left Thursday night's 103-88 loss to the Sacramento Kings with a chest contusion. X-Rays were negative, but coach Tom Thibodeau said before the game that Hinrich was day-to-day.