George Selvie will replace Ayers (hamstring), while the Giants will shuffle their line a bit to replace Flowers (ankle), their first-round draft pick. Justin Pugh will move from left guard to tackle and John Jerry will start at guard. Jayron Hosley is starting for Dominique Rodgers-Cromartie (concussion). He was ruled out Wednesday.
Jon Beason (knee) was active for the first time this season and listed to start at middle linebacker.
Redskins quarterback Robert Griffin III was inactive for the third straight game.