FILE - In this Dec. 20, 2015, file photo, Buffalo Bills' Marcell Dareus tackles Washington Redskins tight end Jordan Reed (86) during the first half of an NFL football game in Landover, Md.Bills star defensive tackle Marcell Dareus returns to practice on
Andrew Harnik, File
October 14, 2016

ORCHARD PARK, N.Y. (AP) Buffalo Bills defensive tackle Marcell Dareus is doubtful for Sunday's game against the San Francisco 49ers.

Dareus has yet to play for the Bills this season. He missed the first four games with a suspension after violating the league's substance abuse policy, and injured his hamstring after returning to the practice field last week.

The third overall pick in the 2011 draft, Dareus has been one of Buffalo's best players over the previous five seasons. He has 253 tackles and 30 1-2 sacks in his career.

Nine Bills are questionable, including LB Zach Brown (ankle), LT Cordy Glenn (ankle), S Aaron Williams (ankle), TE Charles Clay (knee) and Dareus' likely replacement, DT Corbin Bryant (ankle).

Brown has been a major addition for the Bills this season and leads the NFL in tackles with 60.

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