Cardinals at 49ers: How to Watch, Listen, TV Coverage Map

The Arizona Cardinals are on the road against the San Francisco 49ers.

Jan 5, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) escapes a tackle by San Francisco 49ers linebacker Fred Warner (54) in the first half at State Farm Stadium. Mandatory Credit: Matt Kartozian-Imagn Images | Matt Kartozian-Imagn Images

Who: Arizona Cardinals (2-0) at San Francisco 49ers (2-0)
What: NFL Regular Season, Week 3
When: Sunday, Sept. 21 at 1:25 PM MST
Where: Levi's Stadium, Santa Clara, CA
Spread: 49ers -1.5

The Arizona Cardinals make their NFC West debut in 2025 with a Week 3 road tilt against the San Francisco 49ers, who are set to play their first game at Levi's Stadium this season after spending the first two weeks on the road.

There's about to be some unique uniform history made by the Cardinals - which you can read more about here.

The division is open for the taking from anybody - leaving this early season matchup as one which could play a major factor when the dust starts to settle on the NFC playoff picture later on.

Here's how to check out the game:

How to Watch Cardinals at 49ers

This game will be broadcast nationally on FOX television, though it's mostly limited to viewers around the west coast as the Dallas Cowboys vs Chicago Bears gets majority of the national stage. Adam Amin (play-by-play), Mark Sanchez (analyst) and Kristina Pink (sideline) will be featured on the broadcast.

Coverage map (Cardinals at 49ers in blue, Cowboys vs Bears in red):

Majority of the country will be watching Dallas vs Chicago (red area) in the FOX late game slate. Blue areas will see Cardinals vs 49ers in Week 3. pic.twitter.com/6N4N86T5gh

— Donnie Druin (@DonnieDruin) September 20, 2025

In-market people should also be able to stream the game on NFL+.

If you're in Arizona, there's a few listening options available (via AZCardinals,com):

NATIONAL RADIO

• ESPN Radio
• Chris Carlin (play-by-play) and Kelly Stouffer (analyst)

CARDINALS RADIO

• Arizona Sports 98.7 FM
• Dave Pasch (play-by-play), A.Q. Shipley (analyst) and Paul Calvisi (sideline)

CARDINALS SPANISH RADIO

• Fuego 106.7 FM
• Luis Hernandez (play-by-play) and Irving Villanueva (analyst)

Cardinals Excited to Play at 49ers

Nov 19, 2023; Santa Clara, California, USA; A view of the outside of the stadium before the game between the San Francisco 49ers and the Tampa Bay Buccaneers at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images | Darren Yamashita-Imagn Images

The Cardinals spoke very highly of playing at Levi's Stadium:

“I would say it's a great vibe there. Great vibe, beautiful stadium. Fans are always electric. Just playing outside, it's usually sunny (against) a divisional opponent. It's all you can ask for. It's a great opportunity to go out there and play on the road. Just love it," said quarterback Kyler Murray.

“Loud, outside obviously, so we'll have to deal with some elements. (It) should be hot, but we won't flinch at that because it's hot today. Every day we practice is hot. They just have to understand their environment. It's their home opener and it's on the road and it's outside. They have good fans," head coach Jonathan Gannon added.

Winner gets to move to 3-0 on the season and remain atop the division.