The Mexico forward came off the bench and delivered a beautiful strike from outside the area.
Javier "Chicharito" Hernandez didn't take long to get back on the scoresheet after the international break.
Chicharito curled in a beautiful 20-yard shot to give Bayer Leverkusen a 2-0 lead over Wolfsburg in the first match for both teams after the FIFA window. Chicharito, who scored in one of Mexico's two World Cup qualifying wins over Canada, started the match on the bench and came on just after the hour mark. Within 13 minutes, he was back on the scoresheet, and he did so in atypical fashion, by his standards. Normally a poacher from in close, El Tri's star had a go from outside the box and bent his effort inside the far post.
The goal came amid a bit of controversy, as Leverkusen played on despite Wolfsburg center back Dante being down on the field after suffering an injury in a collision with Chicharito.
For Hernandez, it was his first goal in six club games for Leverkusen and his 15th in league play all season. It was his 24th in all competitions.
He later added an assist, deftly laying the ball off for fellow sub Vladen Yurchenko, who scored on a low, first-time blast to secure the result.