Isner fell in the quarterfinals at the 2012 Olympics in London.
Top-ranked American male John Isner will skip the Rio Olympics, he told The Atlanta Journal-Constitution.
“It’s a decision I didn’t take lightly,” Isner said.
Isner reached the quarterfinals of the men's singles event at the 2012 Olympics, falling to eventual runner–up Roger Federer.
Isner’s decision comes as a result of scheduling conflicts over the summer, due to the BB&T Atlanta Open, which will be played between July 30 and Aug. 7.
“Logistically, it would be pretty much impossible for me to do both,” the 30-year-old said.
Following the Atlanta tournament, Isner will turn his attention on participating in the Western & Southern Open and the U.S. Open.
Isner is currently ranked No. 16 in the world.