With less than four minutes remaining in the second half, Weber dribbled into the lane, jumped and landed in front of a Spiders defender. When he leapt a second time, Weber passed the ball to a teammate and clutched his right knee.
After the play, he lay on the court in pain. Weber later returned to the bench on crutches.
In the loss, the senior finished with 11 points, six steals and three rebounds. Over 19 games this season, he is averaging 7.9 points, 4.4 assists, 3.7 rebounds and a nation-high 3.8 steals per game.
The defeat dropped the Rams to 17-4 (7-1 Atlantic 10). VCU will play at George Mason on Wednesday.