Pujols had tied Mantle on Tuesday night with home run No. 536.
It was Pujols' ninth home run in his last 13 games. He has 17 on the season to go along with a .267 average and 32 RBIs.
The Angels went on to defeat the Rays 6–2 on Thursday.
You can watch Pujols' historic home run below. Next on the home run list is Mike Schmidt, who finished his career with 548.
- Molly Geary