Malcolm Gladwell, a writer for The New Yorker and a bestselling author, described football as a "moral abomination" in an interview with Bloomberg News.
Recent research has increasingly linked football to brain damage and degenerative mental conditions.
"Can you point to another industry in America in which, in the course of doing business, maims a third of its employees?" Gladwell asked.
Gladwell responded to a question about whether he thinks football will disappear.
"I don't see how it doesn't ... It'll start to shrivel up at the high school and college level and then the pro game I think will eventually wither on the vine," he said.
This is not the first time Gladwell has expressed views critical of football. In a 2009 article published in The New Yorker, Gladwell outlines a comparison between football and dogfighting.
Gladwell was also involved in a 2012 debate over whether football should be banned.