Buccaneers vs. Bills Week 8 Odds, Best Bets and Predictions

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The Buccaneers and Bills are set to meet on Thursday night in a game both teams need badly. Tampa Bay (3–3) has dropped three out of four while Buffalo (4–3) lost two of its last three.
The oddsmakers at SI Sportsbook list the Bills as 8.5-point home favorites on Thursday Night Football at Highmark Stadium. The over/under is set at 42.5 points, which gives the Buccaneers an implied point total of 17.
Tampa Bay is undefeated on the road but the Bills have also been perfect in Orchard Park, NY, this season. Josh Allen is 0–1 all-time against the Buccaneers while Baker Mayfield won his only start against Buffalo while he was with Cleveland.
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Buccaneers vs. Bills Odds and Game Info
Moneyline: Buccaneers (+330) | Bills (-450)
Spread: TB +8.5 (-110) | BUF -8.5 (-110)
Total: 41.5 — Over (-110) | Under (-110)
Game Info: Thursday, Oct. 26, 8:15 p.m. ET | Prime Video
Buccaneers vs. Bills Prediction:
Best Bet: Under 41.5 (-110)
Tampa Bay and Buffalo Key Stats and Fun Facts:
- The Bills are second in the NFL in takeaways (eight interceptions and six fumble recoveries) while the Buccaneers are tied for third (six interceptions, seven fumble recoveries).
- This is Tampa Bay’s largest underdog position of the season. The Buccaneers are 2–2 against the spread as an underdog with two outright wins.
- Josh Allen is tied for the second-most passing touchdowns in the NFL (15) with Patrick Mahomes and Tua Tagovailoa.
Tampa Bay’s offense has let the team down in each of its losses this season. The Buccaneers’ top-10 defense allows just 17.3 points per game and has allowed 20-plus points twice, but their offense has scored just 10 points per game in losses compared to 24.3 in wins.
Mike Evans scored the team’s only touchdown in a 16–13 defeat to the Falcons on Sunday. Mayfield threw an interception for the fourth game in a row and one of the league’s worst running games never got off the ground as Rachaad White was held under 4.0 yards per carry for the fifth time this year.
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Mayfield has excelled on the road this season with five touchdowns and just one interception in wins over Minnesota and New Orleans. However, he might have a tough time throwing on Buffalo’s secondary, which allows just over 200 passing yards per game. Teams have been able to exploit the Bills on the ground to the tune of 128 rushing yards on average, though the Buccaneers have only broken 100 rushing yards twice in six games.
Buffalo’s offense has slowed down significantly since its three-game winning streak during which it averaged over 40 points per game. However, it’s the Bills defense that’s cause for concern at the moment. That unit allowed 25 points to the Jaguars in a loss three weeks ago and a season-high 29 to the Patriots on Sunday.
Allen and Stefon Diggs should have some success against the Tampa Bay defense, which holds up better against the run than the pass. But even so, Diggs was largely contained last week by New England and Allen was held under 200 passing yards the week prior against New York.
The under has hit in four straight games for the Buccaneers and in all but one of their contests this season. It’s also hit more often than not for the Bills, who should be able to keep Mayfield contained but are in the midst of a rough patch on offense themselves.
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Kyle is based in Washington, D.C. He writes the Winners Club newsletter and is a fantasy and betting writer for SI. His work has appeared in the Tampa Bay Times, Orlando Sentinel, Miami Herald and Gainesville Sun.
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