Chiefs vs. Giants Prediction, Odds, Spread, Injuries, Trends for NFL Week 3

The Kansas City Chiefs have started 0-2 for the first time in the Patrick Mahomes era. Things have not gone well for the defending AFC champions, but they have a chance to turn things around on Sunday Night Football when they head to MetLife to take on the New York Giants.

The Giants are 0-2, but they took the Dallas Cowboys to the brink in Week 2, and Russell Wilson threw for 450 yards. Can they put together another strong performance on Sunday?

Let's dive into the odds and my best bet.

Chiefs vs. Giants Odds, Spread, and Total

Odds via DraftKings Sportsbook

Spread

Chiefs -6 (-110)
Giants +6 (-110)

Moneyline

Chiefs -305
Giants +245

Total

OVER 45.5 (-108)
UNDER 45.5 (-112)

Chiefs vs. Giants How to Watch

Date: Sunday, Sept 21
Game Time: 8:20 pm ET
Venue: MetLife Stadium
How to Watch (TV): NBC
Chiefs Record: 0-2
Giants Record: 0-2

Chiefs vs. Giants Betting Trends

Chiefs are 1-5 ATS in their last six games
Giants are 9-1 ATS in their last 10 games vs. Chiefs
The UNDER is 5-2 in the Chiefs' last seven games vs. NFC East opponents
Giants are 3-11 ATS in their last 14 games
The UNDER is 13-7 in the Giants' last 20 games
Giants are 1-8 straight up in their last nine games

Chiefs vs. Giants Injury Reports

Chiefs Injury Report

Xavier Worthy, WR - Questionable
Jalen Royals, WR - Questionable
Kristian Fulton, CB - Questionable
Mike Danna, DE - Questionable
Nazeeh Johnson, S - IR-R

Giants Injury Report

Anthony Johnson Jr., S - PUP-R
Chris Board, LB - IR
Andrew Thomas, OT - Questionable
Rakeem Nunez-Roches, DT - Questionable
Demetrius Flannigan-Fowles, LB - Questionable

Chiefs vs. Giants Key Player to Watch

Patrick Mahomes, QB - Kansas City Chiefs

Patrick Mahomes isn't getting much help offensively, but he still has to find a way to turn things around. He has completed just 58.8% of passes through the first two weeks, averaging 6.5 yards per throw, two touchdowns, and one interception. If he can't find a way to be more effective, the Chiefs are going to miss the entire playoffs, let alone winning a 10th straight AFC West title.

Chiefs vs. Giants Prediction and Pick

In this week's edition of the Road to 272 Bets, I broke down why I'm laying the points with the Chiefs:

The Kansas City Chiefs have looked bad in the first two weeks, but let's cut them a bit of slack, considering how their first two opponents were. The Chargers and the Eagles are tough teams to face, and now they get to face the lowly New York Giants. Let's also point out the Chiefs have a Net Yards per Play of +0.5 through the first two games, which is a better mark than they had last season when they went 15-2.

I'm not looking too far into Russell Wilson throwing for 450 yards against the Cowboys. We've seen enough from him the past few years to know that last week's performance was an anomaly. Despite having a far easier schedule to start the season, the Giants' advanced metrics are on par with the Chiefs, while ranking worse in Net Yards per Play at -0.3.

I'll lay the points on the Chiefs in a big bounce back spot on Sunday night.

Pick: Chiefs -6 (-110) via DraftKings

Claim the latest DraftKings promo code offer today. Sign up and place a $5 bet to earn a guaranteed $200 in bonus bets plus over $200 off NFL Sunday Ticket. Regardless of the outcome of your wager, DraftKings will add eight $25 bonus bet tokens to your new account and award one promo code for a discounted NFL Sunday ticket subscription.

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

You can check out all of Iain's bets here!