Giants vs. Padres Prediction, Odds, Probable Pitchers, Prop Bets for Wednesday, April 1

The San Francisco Giants are looking to complete the sweep of the San Diego Padres on Wednesday afternoon.

After scoring just one run while getting swept by the Yankees, the Giants have outscored the Padres 12-5 through two games in San Diego. The Friars have been held to three runs or fewer in each of their first five games.

Adrian Houser is set to make his Giants debut opposed by Nick Pivetta for San Diego.

Here are the odds, probable pitchers, and predictions for Giants vs. Padres on Wednesday, April 1.

Giants vs. Padres Odds, Run Line and Total

Odds via DraftKings Sportsbook

Run Line

Giants +1.5 (-171)
Padres -1.5 (+141)

Moneyline

Giants +129
Padres -156

Total

8.0 (Over -105/Under -115)

Giants vs. Padres Probable Pitchers

Giants: Adrian Houser (8-5, 3.31 ERA in 2025)
Padres: Nick Pivetta (0-1, 18.00 ERA)

Giants vs. Padres How to Watch

Date: Wednesday, April 1
Time: 4:10 p.m. ET
Venue: Petco Park
How to Watch (TV): NBCSBA, SDPA
Giants record: 2-3
Padres record: 1-4

Giants vs. Padres Best MLB Prop Bets

Giants Best MLB Prop Bet

Jung Hoo Lee OVER 1.5 Hits + Runs + RBIs (+119)

Jung Hoo Lee had a slow start to the season with just one hit (a double) through 13 at-bats in his first four games. However, he had three hits (two doubles) and three RBI last night in San Diego, and hit Nick Pivetta well last season.

Lee went 6 for 12 against Pivetta with a home run and three doubles. I’ll take a chance on him to stay hot against a familiar foe after a strong showing last night.

Giants vs. Padres Prediction and Pick

I’m not putting too much stock into the Giants’ nine-run outburst on Tuesday night. Neither of these teams has swung the bat well to start the season, and both pitchers are coming off strong performances last year.

Pivetta had some success against the Giants last season, so I’m expecting him to shake off his first outing pretty quickly.

I’ll fade both offenses today in San Diego.

Pick: UNDER 8 (-115)

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Odds refresh periodically and are subject to change.

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