NFL Straight-Up Moneyline Picks for Every Game in Week 2

As it usually does, Week 1 of the 2026 NFL season brought plenty of surprising results, including the Arizona Cardinals upsetting the Los Angeles Chargers and the New York Giants taking down the Dallas Cowboys on Sunday Night Football.

Congratulations to the two newcomers in the SI Betting Panel, Eva Geitheim and Mike Kadlick, who were the only two members of the roundtable who have a profitable record after the opening week of the season.

Let's take a look at how everyone dead and then we'll dive into everyone's plays for Week 2.

NFL Week 1 Results

Albert Breer, Senior Writer: 10-6 (-0.24 units)
Eva Geitheim, NFL Writer: 12-4 (+3.85 units)
Mitch Goldich, Senior Editor: 9-7 (-2.30 units)
Mike Kadlick, NFL Senior News Writer: 12-4 (+4.02 units)
Gilberto Manzano, NFL Staff Writer: 8-8 (-3.87 units)
Conor Orr, Senior Writer: 5-12 (-7.93 units)
John Pluym, NFL Managing Editor: 10-6 (-0.78 units)
Matt Verderame, NFL Staff Writer: 10-6 (-1 unit)
Iain MacMillan, Senior Editor, Betting: 8-8 (-2.65 units)
Peter Dewey, Associate Managing Editor, Betting: 9-7 (-2.23 units)

NFL Week 2 Picks

All odds listed are via DraftKings Sportsbook

Lions (+190) vs. Bills (-230)

Albert Breer: Bills
Eva Geitheim: Bills
Mitch Goldich: Bills
Mike Kadlick: Bills
Gilberto Manzano: Bills
Conor Orr: Bills
John Pluym: Bills
Matt Verderame: Bills
Iain MacMillan: Lions
Peter Dewey: Bills

Panthers (-135) vs. Falcons (+114)

Albert Breer: Panthers
Eva Geitheim: Panthers
Mitch Goldich: Panthers
Mike Kadlick: Panthers
Gilberto Manzano: Panthers
Conor Orr: Panthers
John Pluym: Falcons
Matt Verderame: Panthers
Iain MacMillan: Panthers
Peter Dewey: Panthers

Vikings (+180) vs. Bears (-218)

Albert Breer: Bears
Eva Geitheim: Vikings
Mitch Goldich: Bears
Mike Kadlick: Bears
Gilberto Manzano: Bears
Conor Orr: Vikings
John Pluym: Bears
Matt Verderame: Bears
Iain MacMillan: Vikings
Peter Dewey: Bears

Eagles (-325) vs. Titans (+260)

Albert Breer: Eagles
Eva Geitheim: Eagles
Mitch Goldich: Eagles
Mike Kadlick: Eagles
Gilberto Manzano: Eagles
Conor Orr: Eagles
John Pluym: Eagles
Matt Verderame: Eagles
Iain MacMillan: Eagles
Peter Dewey: Eagles

Steelers (+180) vs. Patriots (-218)

Albert Breer: Patriots
Eva Geitheim: Patriots
Mitch Goldich: Steelers
Mike Kadlick: Patriots
Gilberto Manzano: Patriots
Conor Orr: Patriots
John Pluym: Patriots
Matt Verderame: Patriots
Iain MacMillan: Patriots
Peter Dewey: Patriots

Packers (-205) vs. Jets (+170)

Albert Breer: Packers
Eva Geitheim: Jets
Mitch Goldich: Packers
Mike Kadlick: Packers
Gilberto Manzano: Packers
Conor Orr: Packers
John Pluym: Jets
Matt Verderame: Packers
Iain MacMillan: Packers
Peter Dewey: Packers

Browns (+310) vs. Buccaneers (-395)

Albert Breer: Buccaneers
Eva Geitheim: Buccaneers
Mitch Goldich: Buccaneers
Mike Kadlick: Buccaneers
Gilberto Manzano: Buccaneers
Conor Orr: Buccaneers
John Pluym: Buccaneers
Matt Verderame: Buccaneers
Iain MacMillan: Buccaneers
Peter Dewey: Buccaneers

Saints (+320) vs. Ravens (-410)

Albert Breer: Ravens
Eva Geitheim: Ravens
Mitch Goldich: Ravens
Mike Kadlick: Ravens
Gilberto Manzano: Ravens
Conor Orr: Ravens
John Pluym: Ravens
Matt Verderame: Ravens
Iain MacMillan: Ravens
Peter Dewey: Ravens

Bengals (+124) vs. Texans (-148)

Albert Breer: Bengals
Eva Geitheim: Texans
Mitch Goldich: Texans
Mike Kadlick: Bengals
Gilberto Manzano: Bengals
Conor Orr: Texans
John Pluym: Texans
Matt Verderame: Texans
Iain MacMillan: Texans
Peter Dewey: Bengals

Jaguars (+124) vs. Broncos (-148)

Albert Breer: Broncos
Eva Geitheim: Jaguars
Mitch Goldich: Jaguars
Mike Kadlick: Jaguars
Gilberto Manzano: Jaguars
Conor Orr: Broncos
John Pluym: Jaguars
Matt Verderame: Broncos
Iain MacMillan: Jaguars
Peter Dewey: Jaguars

Raiders (+240) vs. Chargers (-298)

Albert Breer: Chargers
Eva Geitheim: Chargers
Mitch Goldich: Chargers
Mike Kadlick: Chargers
Gilberto Manzano: Raiders
Conor Orr: Chargers
John Pluym: Chargers
Matt Verderame: Raiders
Iain MacMillan: Chargers
Peter Dewey: Chargers

Commanders (+185) vs. Cowboys (-225)

Albert Breer: Cowboys
Eva Geitheim: Commanders
Mitch Goldich: Cowboys
Mike Kadlick: Cowboys
Gilberto Manzano: Cowboys
Conor Orr: Cowboys
John Pluym: Cowboys
Matt Verderame: Cowboys
Iain MacMillan: Commanders
Peter Dewey: Cowboys

Seahawks (-205) vs. Cardinals (+170)

Albert Breer: Seahawks
Eva Geitheim: Seahawks
Mitch Goldich: Seahawks
Mike Kadlick: Seahawks
Gilberto Manzano: Seahawks
Conor Orr: Seahawks
John Pluym: Seahawks
Matt Verderame: Seahawks
Iain MacMillan: Seahawks
Peter Dewey: Seahawks

Dolphins (+625) vs. 49ers (-950)

Albert Breer: 49ers
Eva Geitheim: 49ers
Mitch Goldich: 49ers
Mike Kadlick: 49ers
Gilberto Manzano: 49ers
Conor Orr: 49ers
John Pluym: 49ers
Matt Verderame: 49ers
Iain MacMillan: 49ers
Peter Dewey: 49ers

Colts (+230) vs. Chiefs (-285)

Albert Breer: Chiefs
Eva Geitheim: Chiefs
Mitch Goldich: Chiefs
Mike Kadlick: Chiefs
Gilberto Manzano: Chiefs
Conor Orr: Chiefs
John Pluym: Chiefs
Matt Verderame: Chiefs
Iain MacMillan: Chiefs
Peter Dewey: Chiefs

Giants (+280) vs. Rams (-355)

Albert Breer: Rams
Eva Geitheim: Rams
Mitch Goldich: Rams
Mike Kadlick: Rams
Gilberto Manzano: Giants
Conor Orr: Rams
John Pluym: Rams
Matt Verderame: Rams
Iain MacMillan: Rams
Peter Dewey: Rams

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