Pitt vs. Virginia Tech Prediction, Odds and Key Players to Watch for College Football Week 5

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The Pittsburgh Panthers and Virginia Tech Hokies have both started with a 4-0 record this season. Pittsburgh has gotten past Miami-Ohio, UCF, Syracuse, and Bucknell, while Virginia Tech has defeated VMI, Old Dominion, Maryland, and Boston College.
Someone's undefeated record will move to 5-0 on Friday night, while the other team will suffer its first loss of the season. Let's dive into the odds and my best bet for this ACC showdown.
Pittsburgh vs. Virginia Tech Odds, Spread, and Total
Spread
- Pittsburgh +3.5 (-115)
- Virginia Tech -3.5 (-102)
Moneyline
- Pittsburgh +135
- Virginia Tech -165
Total
- OVER 53.5 (-110)
- UNDER 53.5 (-108)
Pittsburgh vs. Virginia Tech How to Watch
- Date: Friday, October 2
- Time: 7:00 ET
- Venue: Lane Stadium
- How to Watch (TV): ESPN
- Pittsburgh record: 4-0
- Virginia Tech record: 4-0
Pittsburgh vs. Virginia Tech Betting Trends
- Pittsburgh is 8-2 against the spread in its last 10 games against Virginia Tech
- Pittsburgh is 6-4 against the spread in its last 10 games
- The UNDER is 6-4 in Pittsburgh's last 10 games
- The OVER is 6-4 in Virginia Tech's last 10 games
Pittsburgh vs. Virginia Tech Key Player to Watch
- Jeffrey Overton Jr., RB - Virginia Tech Hokies
Virginia Tech would be smart to continue to lean on their running back, Jeffrey Overton Jr., who has averaged 6.8 yards per carry through his first 60 touches this season. Marcellous Hawkins Jr. hasn't been nearly as effective, averaging only 4.1 yards per carry. If they decide to start giving Overton the bulk of the carries, the Virginia Tech offense will be even more dangerous moving forward.
Pittsburgh vs. Virginia Tech Prediction and Best Bet
Defense is going to be the difference-maker in this game. Pittsburgh's defense has been fantastic to start the season, ranking 16th in adjusted EPA per play, 30th in opponent yards per play, and 14th in opponent success rate. By comparison, Virginia Tech's defense ranks 104th, 110th, and 125th in those three defensive metrics.
While there's a lot I like about the Hokies' offense, their defensive numbers compared to Pittsburgh's make me concerned about their ability to cover the spread as 3.5-point favorites.
I'll take the points with the Panthers.
Pick: Pittsburgh +3.5 (-115) via BetMGM
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Originally from Nova Scotia, Iain MacMillan is a senior editor covering betting, with a focus on NFL, NHL, and golf. He hosts the Bacon Bets Podcast and has been featured on VSIN, BetQL and Monumental Sports Network. He is a member of the Metropolitan Golf Writers Association and his beloved Falcons and Maple Leafs break his heart on a yearly basis.
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