Start ‘Em, Sit 'Em is the ultimate look at the best and worst matchups based on a PPR scoring system in fantasy football. This column will not cover the elite players in the NFL like Patrick Mahomes, Christian McCaffrey, Davante Adams, or Travis Kelce. Instead, I'll look at the players you have the most questions about to help you set the most effective starting lineup possible. For all of your final fantasy lineup decisions, be sure to check out my weekly player rankings which will be updated daily throughout the 2021 NFL season.
Byes: Bears, Bengals, Giants, Texans
Week 10 Start' Em: Wide Receivers
Start of the Week
Michael Pittman Jr. vs. Jaguars (1 p.m. ET, CBS): Pittman has been a star in recent weeks, scoring 17+ fantasy points in four of his last five games, including two with more than 20 points. I like him to post another great line this week as the Colts face the Jaguars at Lucas Oil Stadium. Their defense has allowed eight wide receivers to score at least 16.2 fantasy points, so Pittman is in a true smash spot for fantasy managers.
Mike Williams vs. Vikings (4:05 p.m. ET, Fox): Williams has been a fantasy train wreck in recent weeks, as he's failed to score more than 7.8 fantasy points in four of his last five games. I think this could be the week he busts out of his slump. However, this matchup versus the Vikings is favorable. Their defense has allowed the seventh-most fantasy points to receivers, and six have gone over 100 receiving yards against them.
Christian Kirk vs. Panthers (4:05 p.m. ET, Fox): Kirk is coming off a strong stat line, scoring 16.4 fantasy points in a win over the 49ers. Of course, he did it in a game that saw DeAndre Hopkins and A.J. Green both sidelined. If Nuk returns (Green will be back), then Kirk should be considered a less attractive option. If Nuk remains out, however, I'd start Kirk despite a bad matchup on paper against the Panthers defense.
Marvin Jones Jr. at Colts (1 p.m. ET, CBS): There are four teams on a bye this week, so you'll have to make some dart throws at wide receivers. Jones, based on the matchup, is a worthwhile one. The Colts have allowed the fifth-most fantasy points in the last three weeks, and a total of 11 have scored at least 12 points against them on the season. Jamal Agnew and Laviska Shenault are also in the mix, but Jones is the best bet for me.
Hunter Renfrow vs. Chiefs (8:20 p.m. ET, NBC): Renfrow has emerged into a sort of Wes Welker lite, seeing at least eight targets in four of his last five games. He’s also put up 12+ points in all but two games this year, so he’s had a nice floor because of his target share. This season, the Chiefs have given up good totals to fellow slot receivers like Keenan Allen and Jarvis Landry, so start Renfrow as an attractive flex option.
- Tyler Lockett at Packers (4:25 p.m. ET, CBS)
- Jerry Jeudy vs. Eagles (4:25 p.m. ET, CBS)
- Marquez Callaway vs. Titans (1 p.m. ET, CBS)
- Michael Pittman Jr. vs. Jaguars ($6,300)
- Jerry Jeudy vs. Eagles ($5,300)
- Deonte Harris at Titans ($4,000)
Week 10 Sit' Em: Wide Receivers
Sit of the Week
Courtland Sutton vs. Eagles (4:25 p.m. ET, CBS): Sutton’s totals have crashed in recent weeks, he’s scored a combined 21.7 fantasy points in his last three games. Next is a tough matchup against CB Darius Slay and the Eagles, who have allowed three touchdowns and the third-fewest fantasy points per game to opposing receivers lined out wide. With Jerry Jeudy back and looking good, Sutton is a risk-reward choice.
D.J. Moore vs. Cardinals (4:05 p.m. ET, Fox): Moore is going to be tough to sit with four teams on a bye, so consider this a "beware." Sam Darnold has been just awful in recent weeks, and now Moore will be catching passes from backup P.J. Walker. He's failed to score more than 10.9 points in all but one of his last four games, and the Cardinals have also allowed just 22.1 points per game to receivers lined out wide.
DeVonta Smith at Broncos (4:25 p.m. ET, CBS): Smith did well against a patchwork Chargers defense last week, posting 116 yards and one touchdown. However, I'd still beware an upcoming matchup against the Broncos. Their defense has allowed just three touchdowns to wideouts in their last three games, and the position has averaged a mere 117.3 receiving yards in that time. Start the rookie wideout with tempered expectations.
Brandon Aiyuk vs. Rams (Mon. 8:15 p.m. ET, ESPN): Aiyuk has started to get hot, as he's scored a combined 29.2 fantasy points in his last two games, including 18.7 in his last contest. Still, an upcoming matchup against the Rams is not favorable. This unit held the duo of A.J. Brown and Julio Jones to just 16.7 fantasy points last week, albeit in a positive game script, so I’d beware Aiyuk as more than a risk-reward flex option.
Watch NFL games online all season long with fuboTV: Start with a 7-day free trial!
Elijah Moore vs. Bills (1 p.m. ET, CBS): Moore was a hit add off the waiver wire this week, as he put up a breakout performance in his last game against the Colts. I wouldn't chase the points though, as the Jets will have Corey Davis back in the fold this weekend. The matchup is a difficult one too, as the Bills have allowed the fewest fantasy points per game to wideouts and will be rather salty after a bad loss to the lowly Jaguars.
- Jarvis Landry at Patriots (1 p.m. ET, Fox)
- Jamison Crowder vs. Bills (1 p.m. ET, CBS)
- Jakobi Meyers vs. Browns (1 p.m. ET, CBS)
- D.J. Moore at Cardinals ($6,300)
- DeVonta Smith at Broncos ($5,900)
- Courtland Sutton vs. Eagles ($5,600)
Michael Fabiano is an award-winning fantasy football analyst on Sports Illustrated and a member of the Fantasy Sports Writers Association (FSWA) Hall of Fame. Click here to read all his articles here on SI Fantasy. You can follow Michael on Twitter, Facebook, YouTube, and Instagram for your late-breaking fantasy news and the best analysis in the business!
Sports Illustrated may receive compensation for some links to products and services on this website.