NFL Week 6 Expert Picks, Best Bets Against the Spread

Week 6 in the NFL is expected to see a lot of tight games, as 12 of the 14 games have a spread of a touchdown or less. Below are our experts picking the games against the spread this season, along with each of their picks against the spread and best bets for this weekend's slate. 

Gary Gramling, Senior Editor
Max Meyer, Producer, SI Gambling Vertical
Jimmy Traina, SI Media Columnist

Season Standings
Gramling 38-23-2
Meyer: 31-30-2
Traina 27-34-2

BEST BETS

New York Giants at New England Patriots (-17)

I like Daniel Jones as much as the next guy, but with no Saquon Barkley, Evan Engram and Sterling Shepard, what's the point in even taking the field at Foxboro? Throw in the Thursday night homefield advantage for the Patriots, and the fact that their up-and-down offensive line won't have any issues against a dormant Giants pass rush, and you have another easy victory for a team that's won three of its five games by 20-plus points—and it would have four of five if not for a muffed punt TD and pick-six of Jarrett Stidham against the Jets. —Gary Gramling

New Orleans Saints (+1) at Jacksonville Jaguars

Teddy Bridgewater is doing a fine job filling in for Drew Brees and that will continue on Sunday. The Jaguars are coming off back-to-back-road games in Denver and Carolina and have to be worn down a little after two very physical battles. It'll be three in a row on that front Sunday thanks to New Orleans' defense, which will be Gardner Minshew's biggest test so far. Take the Saints. —Jimmy Traina

Seattle Seahawks at Cleveland Browns (+1.5)

To me, this seems like a classic overreaction spot. The Browns just got humiliated on Monday night against a legitimate Super Bowl contender in the 49ers. The Seahawks squeaked by last year's NFC champion Rams on Thursday night. Those two results in standalone games are a major factor in us now getting the Browns as a home underdog. 

Russell Wilson is an MVP frontrunner so far, but there isn't much to love among the rest of this Seattle team. Brian Schottenheimer's play calls are still archaic in today's age of football. Seattle's defensive sack rate is 25th in the NFL, which should be a boost for Baker Mayfield and Cleveland's offensive line. And the Seahawks' talent in the secondary isn't close to the "Legion of Boom" years, which means we may get an Odell Beckham Jr. breakout game. 

Remember what happened after the Browns' clunker against the Rams on primetime in Week 3? They were a seven-point underdog at the Ravens, and I thought that line was inflated, so I made it my best bet that week. Sure enough, Cleveland won by 15. Take advantage of another overreaction line here, as the Browns will win this game outright. —Max Meyer

Season record: 10-5