Cano sustained the injury after getting hit by a pitch in the seventh inning of the Japan All-Star Series. He suffered a non-displaced fracture of the baby toe on his right foot.
"It's part of the game, getting hurt," Cano, who is expected to be back by spring training, told MLB.com. "I'll be fine."
In his first season with Seattle, Cano hit .314 with 14 home runs and 82 RBI. The five-time All-Star signed a 10-year, $240 million with the Mariners in December 2013.
The Japan All-Star Series, which features MLB players taking on Japan's national team, will wrap up at the Tokyo Dome on Sunday.
-- Alex Suskind