Tigers QB Cullen Harper threw for two touchdowns and ran for another and star RB James Davis (pictured) broke a 70-yard touchdown run, as Clemson rampaged to its seventh win.
No. 24 Tennessee 59, UL-Lafayette 7
Arian Foster ran for 100 yards and two touchdowns as the Volunteers piled up for a season-high 273 yards on the ground in their most lopsided win since a 70-3 homecoming victory over Louisiana-Monroe in 2000.
Arkansas 48, No. 23 South Carolina 36
Darren McFadden ran for an SEC-record 323 yards, ran for a touchdown and also threw for a one as the Razorbacks knocked off the Gamecocks in Fayetteville.
Virginia 17, No. 21 Wake Forest 16
Maurice Covington (80) hauled in a 39-yard touchdown pass as the Cavaliers notched their third one-point victory in four games.
No. 21 Boise State 42, San Jose State 7
Jeremy Avery ran for 56 yards and a touchdown as the Broncos beat San Jose State for the eighth straight time.
Cincinnati 38, No. 20 South Florida 37
Ben Mauk passed for three touchdowns as the Bearcats handed the once second-ranked Bulls their third straight loss.
No. 19 Auburn 35, Tennessee Tech 3
Walter McFadden returned an interception 93 yards for a touchdown, the third longest interception return in Auburn history as the Tigers beat the Golden Eagles.
No. 18 Florida 49, Vanderbilt 22
Percy Harvin ran 11 times for 113 yards and two touchdowns and caught nine balls for 110 yards as the Gators extended their winning streak against Vandy to 17 games.
No. 16 UConn 38, Rutgers 19
Donald Brown came off the bench to run for 154 yards and a touchdown as the Huskies improved to 8-1 for the first time.
No. 15 Michigan 28, Michigan State 24
Mike Hart ran for 118 yards on 15 carries as the Wolverines won for the eighth straight time after losing the first two games of the season.
No. 14 Texas 38, Oklahoma State 35
Ryan Bailey kicked a 40-yard field goal as time expired to cap the Longhorns' rally from a 35-14 deficit entering the fourth quarter.
No. 13 USC 24, Oregon State 3
Chauncey Washington ran for two touchdowns against the nation's No. 1 team against the run as the Trojans beat Oregon State for the 31st time in their last 33 meetings.
No. 11 Virginia Tech 27, Georgia Tech 3
Sean Glennon's jersey mysteriously disappeared prior to Thursday night's game, but the Hokies QB thrived in a makeshift jersey provided by the Yellow Jackets, throwing for 296 yards and two touchdowns.
No. 10 Georgia 44, Troy 34
Knowshon Moreno rushed for 196 yards and three touchdowns, joining Herschel Walker as the only freshmen in Georgia history to rush for 1,000 yards in a season as the Bulldogs edged Troy.
No. 9 Missouri 55, Colorado 10
Jeremy Maclin had 187 all-purpose yards, giving him 1,682 on the season to break the team's single-season record of Devin West.
No. 8 Kansas 76, Nebraska 39
Kerry Meier (10) caught a touchdown pass, one of a Kansas-record six from Todd Reesing as the Jayhawks piled up the most points ever scored on the Huskers in the program's 117-year history.
No. 5 Oklahoma 42, Texas A&M 14
Sam Bradford passed for 284 yards and five touchdowns as the Sooners took sole possession of first place in the Big 12 South.
No. 4 Oregon 35, No. 6 Arizona State 23
Dennis Dixon threw four touchdown passes before leaving with an apparent injury to his left leg as Oregon beat the Sun Devils.
No. 3 LSU 41, No. 17 Alabama 34
Jacob Hester ran for two touchdowns, including the game-winner with 1:26 to go as the Tigers beat former coach Nick Saban and the Crimson Tide.
Florida State 27, No. 2 Boston College 17
Preston Parker (on ground) opened the game's scoring as the Seminoles made Boston College the fourth second-ranked team to be upset this season.
No. 1 Ohio State 38, Wisconsin 17
Playing without star RB P.J. Hill, the Badgers actually took a 17-10 lead in the third quarter, but the Buckeyes would not be denied. Ohio State finished the game with 28 unanswered points, including three touchdowns by Chris Wells (pictured).