SAN FRANCISCO (4-2) at DENVER (4-1)
Sunday, 8:30 p.m. p.m. ET, NBC
OPENING LINE - Broncos by 6 1/2
RECORD VS. SPREAD - Denver 2-3, San Francisco 2-3-1
SERIES RECORD - 49ers lead 7-6
LAST MEETING - 49ers beat Broncos 24-16, Oct. 31, 2010, in London
AP PRO32 RANKING - 49ers No. 6, Broncos No. 1
49ERS OFFENSE - OVERALL (15), RUSH (7), PASS (18).
49ERS DEFENSE - OVERALL (2), RUSH (5), PASS (2).
BRONCOS OFFENSE - OVERALL (9), RUSH (26), PASS (4).
BRONCOS DEFENSE - OVERALL (4), RUSH (4), PASS (16).
STREAKS, STATS AND NOTES - 49ers and Broncos meeting for first time since London game nearly four years ago. The NFL later fined Denver and then-coach Josh McDaniels $50,000 each because team's video operations director filmed a San Francisco practice, breaking league rules. ... 49ers QB Colin Kaepernick's 80-yard TD pass to WR Brandon Lloyd on Monday night at Rams was team's longest pass play since 2005. ... San Francisco is 13-1 in October under coach Jim Harbaugh. ... 49ers have scored 24 points on first offensive series, tied for most in the league. ... 49ers have had 27 plays of 20 or more yards. ... K Phil Dawson is 4 of 4 from 50 or more yards this season. ... San Francisco converting 46.5 percent of third downs. .... RB Frank Gore has 403 yards rushing this season, more than Denver's top two running backs, Montee Ball and Ronnie Hillman, combined (338). ... Former Broncos CB Perrish Cox has three interceptions for 49ers. ... Broncos making 40th appearance on ''Sunday Night Football.'' They're 14-6 at home in those prime-time matchups. ... QB Peyton Manning is three TDs from breaking Brett Favre's mark (508) for most all-time in league. ... TE Julius Thomas has caught nine TD passes, tied for most receiving scores through five games in NFL history. ... CB Chris Harris Jr. has been thrown at just 27 times, allowing 10 receptions. ... WR Wes Welker has 855 receptions, the most by an undrafted player. ... WR Demaryius Thomas ranks first in NFL with 40 catches of 25 or more yards since 2012. ... Hillman rushed for 100 yards last weekend, becoming fourth player in team history to reach that number in first NFL start. ... LB Von Miller leads team with six sacks.
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