The 2014 No. 1 pick played in four games last season.
“I would say the goal is to get him back on the field on August 17th and then go from there,” O'Brien said, according to the team's website.
Last week, the 2014 NFL draft No. 1 pick was placed on the team's physically unable to perform list.
Clowney played in four games and collected seven tackles as a rookie for the Texans before undergoing season-ending microfracture surgery on his right knee.
The Texans will open preseason play against the San Francisco 49ers on Aug. 15.
- Christopher Chavez