He did not return to the game.
Flowers, a 21-year-old rookie, played against the Dolphins despite re-spraining his ankle last week against the New York Jets. The Week 13 matchup marked the second time this season Flowers had sprained his ankle.
He missed New York’s Week 3 game against the Washington Redskins with his first ankle sprain.
Flowers, a 2014 All-ACC second team honoree, was selected by the Giants in the first round of the 2015 draft out of Miami (FL).
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He has started in nine games this season for New York.