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49ers 53-man roster projection after preseason Week 2

The picture is starting to become clearer.
Feb 27, 2025; Indianapolis, IN, USA; San Francisco 49ers general manager John Lynch speaks during the 2025 NFL Scouting Combine at the Indiana Convention Center. Mandatory Credit: Kirby Lee-Imagn Images
Feb 27, 2025; Indianapolis, IN, USA; San Francisco 49ers general manager John Lynch speaks during the 2025 NFL Scouting Combine at the Indiana Convention Center. Mandatory Credit: Kirby Lee-Imagn Images | Kirby Lee-Imagn Images

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Now that the San Francisco 49ers have played two preseason games, the 53-man roster projection is starting to become a bit clearer. Where does the roster stand with one game to go?

Mac Jones, 49er
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Quarterback (2): Brock Purdy, Mac Jones

Carter Bradley made a case for the practice squad, but that still may not be the case.

San Francisco 49er
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Running Back (4): Christian McCaffrey, Isaac Guerendo, Jordan James, Kyle Juszcyk 

Injuries to Corey Kiner and Patrick Taylor leave them thin here. If Guerendo and James are not ready for Week 1, they are going to be keeping someone they signed a few weeks ago.

Ricky Pearsall, 49er
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Wide Receiver (5): Jauan Jennings, Ricky Pearsall, Jordan Watkins, Jacob Cowing, Russell Gage 

Brandon Aiyuk will start the year on the PUP and Demarcus Robinson is likely to be suspended and off the initial roster. It opens a spot for Junior Bergen, who is just off for now.

49ers, George Kittl
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Tight End (4): George Kittle, Luke Farrell, Jake Tonges, Brayden Willis 

The team cut Ross Dwelley, and they seem to like the versatility of Tonges. However, Tonges being cut to keep the rookie receiver Bergen could come to fruition as well.

San Francisco 49er
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Offensive Line (9): Trent Williams, Ben Bartch, Jake Brendel, Dominick Puni, Colton McKivitz, Spencer Burford, Connor Colby, Nick Zakelj, Drew Moss 

The injury to Dominick Puni and the rise of Drew Moss has the unit keeping nine players. Zakelj has shown enough to leave Matt Hennessy off as the backup center.

Kalia Davis, 49er
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Interior Defensive Line (6): Jordan Elliott, Kevin Givens, CJ West, Alfred Collins, Kalia Davis, Evan Anderson

Kevin Givens is going to the IR, but the team will need to keep him on the initial 53-man roster if they want to give him a designation to return. They could call on a veteran who does not need to clear waivers to release them until they place Givens on IR and sign them back. This could open a roster spot, and that may even go to rookie Sebastian Valdez. The other five seem needed given the depth issues and injuries up front.

Nick Bosa, 49er
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Edge Rushers (4): Nick Bosa, Mykel Williams, Yetur Gross-Matos, Bryce Huff

The injury status of Sam Okuayinonu will determine whether he makes the roster or not. Like Givens, he could make the initial roster just to be placed on the IR.

Dee Winters, 49er
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Linebacker (6): Fred Warner, Dee Winters, Nick Martin, Tatum Bethune, Luke Gifford, Curtis Robinson 

Curtis Robinson and Luke Gifford are prime candidates to get cut, let the team place Givens on the IR, then re-sign the veterans. Do not be shocked if one of them is not on the initial roster.

49ers, Deommodore Lenoi
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Cornerback (6): Deommodore Lenoir, Renardo Green, Upton Stout, Darrell Luter, Dallis Flowers, Chase Lucas

The big name missing is Tre Brown, but for two straight weeks he has played where the fringe roster players have. He has lost out to Luter, Flowers, and Lucas and they do not need a seventh cornerback.

Ji'Ayir Brow
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Safety (4): Jason Pinnock, Richie Grant, Marques Sigle, Ji’Ayir Brown 

Malik Mustapha will be on the IR making this set in stone. The only question is whether Sigle starts.

Special Teams (3): Jake Moody, Thomas Morestead, Jon Weeks

Moody likely solidified his spot on the team with his 59-yard game-winning field goal against the Raiders on Saturday.

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Parker Hurley
PARKER HURLEY

Parker Hurley is a Pittsburgh native and IUP alumni with a deep-rooted passion for football and a decade of experience analyzing the game. Since 2016, he had extensively covered the Chicago Bears, serving as the site manager for Bear Goggles On from 2017 to 2023. During that time, Parker published hundreds of articles per month and led content strategy across written, audio, and video formats. Parker has also produced podcasts, blogs, and YouTube content focused on the Pittsburgh Steelers, NFL betting trends, and league-wide analysis. His work blends film breakdowns, statistical insight, and timely news reaction to deliver clear, actionable content for fans and bettors alike. Now, Parker contributes NFL coverage across multiple platforms, expanding his scope to include teams like the San Francisco 49ers and broader NFL narratives. Whether he’s analyzing rookie development or evaluating playoff contenders, Parker’s top priority is helping readers understand the game on a deeper level. He brings passion, clarity, and consistency to everything he writes, always aiming to educate, engage, and elevate the football conversation.

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