Falcons vs. 49ers Odds, How to Watch, Injuries for NFL Week 7

SANTA CLARA, CA – The Atlanta Falcons are traveling west for a Sunday Night Football showdown against the San Francisco 49ers. Fresh off one of their most complete performances of the season against the Bills, the Falcons are eager to pick up just their second three-game winning streak since the end of the 2019 season.

Awaiting the Falcons are their old division rivals in Santa Clara, who have lost two of their last three after starting 3-0. A likely culprit for their woes is a brutal run of injuries that got that much worse on Sunday with the loss of All-Pro linebacker Fred Warner.

Before that, the 49ers had already been dealt injuries to edge Nick Bosa, guard Ben Bartch, George Kittle, Brandon Aiyuk, Ricky Pearsall, Jauan Jennings, Brock Purdy, and Mac Jones. While a few of those players could make their return on Sunday, the first six weeks of the season have been a brutal run of injury luck for the Falcons’ Week 7 opponent.

“I feel like they’re definitely a sound defense. They don't want to give up the big shots,” quarterback Michael Penix Jr. said. “I feel like that's every defense in the league now. You don't want to give up those big plays, so just taking what they give us. I know they are a fast-flowing defense. Those guys can run sideline to sideline.”

While unfortunate, it is on the Falcons to take advantage of this situation, but the 49ers will always be a difficult challenge.

See below for how you can tune in for this Week 7 game.

Falcons vs. 49ers: Stats to Know

Falcons Offense: 20.0 PPG (27th), 378.8 YPG (2nd), 227.6 Passing YPG (12th), 151.2 Rushing YPG (1st), 22nd in EPA/play
Falcons Defense: 20.0 PPG Allowed (7th), 253.4 YPG Allowed (1st), 139.4 Passing YPG Allowed (1st), 114.0 Rushing YPG Allowed (17th), 6th in EPA/play Allowed

49ers Offense: 20.8 PPG (24th), 373.7 YPG (6th), 291.5 Passing YPG (1st), 82.2 Rushing YPG (30th), 20th in EPA/play
49ers Defense: 21.3 PPG Allowed (15th), 321.7 YPG Allowed (15th), 214.3 Passing YPG Allowed (18th), 107.3 Rushing YPG Allowed (14th), 19th in EPA/play Allowed

Falcons vs. 49ers: Odds, Spread, Total

Odds via BetMGM Sportsbook. Odds refresh periodically and are subject to change. If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

Spread

49ers -2.0 (-110)
Falcons +2.0 (-110)

Moneyline

49ers -135
Falcons +210

Total

OVER 47.0 (-110)
UNDER 47.0 (-110)

Falcons vs. 49ers: How to Watch

Date: Sunday, October 19, 2025
Game Time: 8:20 pm ET
Venue: Levi’s Stadium in Santa Clara, CA
How to Watch (TV): NBC/Peacock
Announcers: Mike Tirico, Cris Collinsworth, Melissa Stark
How to Listen Locally (Falcons Radio Network): 92.9 The Game
Announcers: Wes Durham, Dave Archer
49ers Record: 4-2 (2-1)
Falcons Record: 3-2 (0-2)

Falcons vs. 49ers: Injury Report

49ers Injury Report

DL Kevin Givens (pectoral) – QUES
CB Renardo Green (neck) – QUES
CB Upton Stout (shoulder) – QUES
DL Yetur Gross-Matos (neck) – OUT
WR Ricky Pearsall (knee) – OUT
QB Brock Purdy (toe) – OUT
LB Fred Warner (ankle) – OUT

Falcons Injury Report

WR Darnell Mooney (hamstring) – QUES
T Jake Matthews (ankle) – QUES
TE Feleipe Franks (calf) – QUES
DL Ta'Quon Graham (calf) – QUES
Edge Jalon Walker (groin) – OUT
CB Clark Phillips III (triceps/illness) – OUT
S Jordan Fuller (knee) – OUT
CB Billy Bowman Jr. (hamstring) – OUT
WR Ray-Ray McCloud III (not injury related – other) – OUT