Final Prediction For Jaguars' Clash With 49ers

In today's episode of the Jacksonville Jaguars Insider Podcast, we deliver or final prediction for the Jaguars vs. the San Francisco 49ers.

To watch today's episode, view below.

For a partial transcription of Jaguars defensive coordinator Anthony Campanile's comments on the big game, read below.

On the challenges of a Kyle Shanahan offense

ANTHONY CAMPANILE: "A lot of what I just said before like the pre-snap movement and they're really well coached up front. That's kind of a staple of all his teams I feel like. I think the backs do a great job of running the ball one hole at a time and if you leave a crease in there, they're going to take it. But they're well-trained and well coached at the running back position, offensive line.

I think one of the things that shows up with those teams over the years is the tight ends and receivers block. They do the dirty work and that's usually the staple of any team that runs the ball well. They do a good job making their play-action pass stuff look like the run game, as good as anybody.”

On what he credits the defensive success to so far

ANTHONY CAMPANILE: The players, we have good players. Honestly, that's number one and we have guys that really care. They're trying so hard to get it right. They're very honest with each other and they're honest with me and that helps me because I don't think anything gets better without honesty. There's no job or there's no relationship in the world that honesty can't help you with.

Jacksonville Jaguars defensive coordinator Anthony Campanile hugs safety Andrew Wingard (42) before an NFL football matchup at EverBank Stadium, Sunday, Sept. 21, 2025, in Jacksonville, Fla. The Jaguars defeated the Texans 17-10. | Corey Perrine/Florida Times-Union / USA TODAY NETWORK via Imagn Images

So that's the number one thing, for them to be able to be transparent with me and myself with them and with each other. They're kind of counting on each other, pouring into each other, every day and they're all selling out for each other, not on each other and I think that's what I would attribute any of the success to. To those guys, to the players.”

On if it is helpful having played the 49ers last season

ANTHONY CAMPANILE: “It's definitely a resource. Like anything, anytime you play a team, you're always looking back at that and what you did well, what you didn't do well. I'm sure they're doing the same. So yeah, it's definitely a resource.”

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