The moves do not come as a surprise after both players opened the season on the Sabres' injured list. Pysyk sustained what the team called an ''upper body'' injury during a 2-0 preseason win over Carolina on Sept. 23. McCabe was sidelined by what the team called a ''middle body'' injury before the start of the season.
McCabe was Buffalo's second-round pick in the 2012 draft and had an opportunity to make the Sabres' season-opening roster before getting hurt.
Buffalo (1-3), coming off a 4-3 shootout victory at Carolina on Tuesday, hosts Florida on Friday, and then Boston on Saturday.