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Williams sisters, Murray, del Potro lead lineup at US Open

NEW YORK (AP) Former champions Serena Williams, Andy Murray, Venus Williams and Juan Martin del Potro lead Saturday's lineup at the U.S. Open, all of them seeking to book their spots in the round of 16.

Top-seeded Serena Williams, who is bidding for a record 23rd Grand Slam singles title, takes on 47th-ranked Johanna Larsson of Sweden in Arthur Ashe Stadium. Sister Venus, the sixth seed and oldest woman in the tournament at 36, plays later in Ashe against 26th-seeded Laura Siegemund of Germany.

On the men's side, No 2-seed and 2012 champion Andy Murray plays in the afternoon in Ashe against 40th-ranked Paolo Lorenzi. In the nightcap in Ashe, 14th-seeded Nick Kyrgios gets his chance on center stage, facing 63rd-ranked Illya Marchenko of Ukraine.

The 2009 champion, Juan Martin del Potro, seeks to continue his comeback from wrist injuries with a tough matchup against 11th-seeded David Ferrer in Louis Armstrong Stadium.

Players will face cloudy skies and the coolest weather of the tournament so far, with highs only in the mid 70s.