Hardaway's injury occurred midway through the third quarter. He did not return.
Hardaway Jr., in his second year out of Michigan, entered Wednesday averaging 11.1 points in 22.3 minutes per game, shooting 39.1 percent from the field and 33.1 percent on three-pointers.
The Knicks have dealt with a significant number of injuries this season. Forward Andrea Bargnani missed the first 33 games of the season due to hamstring and calf injuries and guard J.R. Smith had missed the previous 10 games due to a foot injury before both players returned Wednesday.
The Knicks lost to the Clippers 99-78. Their 1-19 record over their last 20 games is their worst performances in a 20-game stretch in franchise history.
New York is in fourth place in the Atlantic Division at 5-29.
- Ben Estes