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Colts vs. Chiefs Final Score Prediction for NFL Week 12 (Can Kansas City Cover?)

Will Kansas City end Week 12 with a losing record?
Patrick Mahomes and the Kansas City Chiefs are favored against the Indianapolis Colts on Sunday.
Patrick Mahomes and the Kansas City Chiefs are favored against the Indianapolis Colts on Sunday. | Ron Chenoy-Imagn Images

The Kansas City Chiefs are in serious danger after dropping to 5-5 following their Week 11 loss to the Denver Broncos. They’ll look to avoid dropping below .500 on the year this weekend and will host the Indianapolis Colts and are 3.5-point favorites on Sunday. Holding off the AFC South’s will likely be difficult.

Indianapolis is now 8-2 on the year and are coming off a bye week after securing their first victory following the Sauce Gardner trade in Week 9. Daniel Jones is having a resurgent year and Jonathan Taylor is performing like one of the best backs in football again. Patrick Mahomes and the rest of the Chiefs’ offense will have to be at their best against the NFL’s top scoring offense. 

Here’s our score prediction for the matchup ahead of kickoff.

Colts vs. Chiefs Odds, Spread and Total

Odds via DraftKings Sportsbook

Spread

  • Colts: +3.5 (-115)
  • Chiefs: -3.5 (-105)

Moneyline

  • Colts: +154
  • Chiefs: -185

Total

  • 50.5 (Over -108/Under -112)

Indianapolis and Kansas City are .500 or better against the spread this season. The Colts boast one of the league’s most productive offenses, but the under has hit in seven of the Chiefs’ 10 games.

Colts vs. Chiefs Final Score Prediction

Kansas City went 5-1 in between Weeks 3 and 8, but it appears like three of the teams they beat are far from the playoff picture and have been eliminated from postseason contention. The Chiefs have lost back-to-back games against winning teams.

Indianapolis, however, has lost and failed to cover in two of its three road games. The Colts have only covered the spread away from home against the 1-9 Tennessee Titans. 

The Chiefs have a top-five scoring defense and their receiving corps is much healthier than it was at the beginning of the season. Mahomes can pick apart the Colts’ secondary and keep his team in the playoff hunt in a narrow win.

Final Score Prediction:  Chiefs 27, Colts 23


Odds refresh periodically and are subject to change.

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Published
Ameer Tyree
AMEER TYREE

Ameer Tyree is a sports betting writer for Sports Illustrated with years of experience covering the NFL, college football, the NBA, the WNBA and the EPL. His work has been featured on The Sporting News, DraftKings Network, CBS Sports and Covers. He strives to find the best value on the board and takes pride in being the world's top James Harden apologist.

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