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Oct 19, 2025; Inglewood, California, USA; Indianapolis Colts defensive tackle DeForest Buckner (99) looks on after the game against the Los Angeles Chargers at SoFi Stadium. Mandatory Credit: Gary A. Vasquez-Imagn Images

Superstar Return for Colts Looking Very Promising for 49ers Matchup

Drake Wally

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6 Hours Ago

Nov 30, 2025; Cleveland, Ohio, USA; The San Francisco 49ers huddle up after the break during the second half against the Cleveland Browns at Huntington Bank Field. Mandatory Credit: Scott Galvin-Imagn Images

49ers Will be Without Two Skilled Starters Against Indianapolis

Jose Sanchez

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7 Hours Ago

Sep 14, 2025; Indianapolis, Indiana, USA; Indianapolis Colts defensive tackle DeForest Buckner (99) celebrates a tackle against Denver Broncos quarterback Bo Nix (10) during the fourth quarter at Lucas Oil Stadium. Mandatory Credit: Robert Goddin-Imagn Images

49ers Make it Clear How They Feel About DeForest Buckner

Jose Sanchez

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7 Hours Ago

Dec 14, 2025; Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) runs with the ball during the first quarter against the Tennessee Titans at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images

Brock Purdy Sounds Off on the Colts’ Defense

Jose Sanchez

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9 Hours Ago

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Colts defensive tackle DeForest Buckner is set to return to the lineup on Monday night.

Colts Receive Good News on DT DeForest Buckner Ahead of Monday’s Game vs. Niners

Mike McDaniel

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10 Hours Ago

Nov 30, 2025; Cleveland, Ohio, USA; Cleveland Browns running back Dylan Sampson (22) runs the ball during the second half against the San Francisco 49ers at Huntington Bank Field. Mandatory Credit: Ken Blaze-Imagn Images

What the Biggest Challenge Will be for the 49ers Against Indianapolis

Jose Sanchez

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11 Hours Ago

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts head coach Shane Steichen stands on the sideline during the fourth quarter against the Seattle Seahawks at Lumen Field.

Three Bold Predictions for Colts' MNF Showdown vs. 49ers

Sean Ackerman

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11 Hours Ago

Indianapolis Colts running back Jonathan Taylor (28) fends off San Francisco 49ers cornerback Josh Norman (26) during the first half of the game Sunday, Oct. 24, 2021, at Levi's Stadium in Santa Clara, Calif.

Indianapolis Colts Visit The San Francisco 49ers For Nfl Week 7 At Levi S Stadium In Santa Clara Calif Sunday Oct 24 2021

NFL Giant Casts Shadow on Colts' Hope to Defeat 49ers

Drake Wally

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12 Hours Ago

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) walks to the locker room following the second quarter against the Seattle Seahawks at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images

Kyle Shanahan Says Colts' Philip Rivers 'One of the Best' He's Watched

Drake Wally

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17 Hours Ago

Highlights from the 1957 Topps Football Set

Brian Hough

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Dec 19, 2025

Sep 14, 2025; Indianapolis, Indiana, USA; Indianapolis Colts defensive tackle DeForest Buckner (99) celebrates a tackle against Denver Broncos quarterback Bo Nix (10) during the fourth quarter at Lucas Oil Stadium.

Colts' Best Defender Trending Toward Return vs. 49ers

Sean Ackerman

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Dec 19, 2025

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) walks to the huddle during the first quarter against the Seattle Seahawks at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images

Colts' Limited Offense Reveals Clear Betting Value vs. 49ers

Michael Greene

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Dec 19, 2025

Oct 2, 2025; Inglewood, California, USA; San Francisco 49ers head coach Kyle Shanahan during the second half at SoFi Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Kyle Shanahan Sounds Off on the Colts’ Run Game

Jose Sanchez

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Dec 19, 2025

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts running back Jonathan Taylor (28) rushes against the Seattle Seahawks during the second half at Lumen Field.

Three Ways Colts Can Cruise to Victory vs. 49ers

Sean Ackerman

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Dec 19, 2025

Dec 14, 2025; New Orleans, Louisiana, USA; New Orleans Saints quarterback Tyler Shough (6) throws the ball during the second quarter against the Carolina Panthers at Caesars Superdome. Mandatory Credit: Matthew Hinton-Imagn Images

NFL Week 16 Survival Pool Strategy: Saints, Texans and 3 More Winning Picks

Michael Rovetto

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Dec 19, 2025

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts quarterback Philip Rivers (17) hands the ball of to running back Jonathan Taylor (28) during the second quarter against the Seattle Seahawks at Lumen Field. Mandatory Credit: Steven Bisig-Imagn Images

How to Catch Colts vs. 49ers Action on Primetime

Drake Wally

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Dec 19, 2025

Dec 14, 2025; Seattle, Washington, USA; Indianapolis Colts head coach Shane Steichen, left, talks with quarterback Philip Rivers (17) during a second quarter timeout against the Seattle Seahawks at Lumen Field. Mandatory Credit: Kevin Ng-Imagn Images

Colts on SI Staff Divided with Predictions in Matchup vs. 49ers

Drake Wally

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Dec 19, 2025

Jordan Love led the Packers to a 28–21 win over the Bears two weeks ago.

Key Matchups, Predictions for Packers-Bears and More NFL Week 16 Games

Matt Verderame

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Dec 19, 2025

Oct 5, 2025; Indianapolis, Indiana, USA; Indianapolis Colts quarterback Anthony Richardson (5) runs onto the field during a game against the Las Vegas Raiders at Lucas Oil Stadium. Mandatory Credit: Grace Smith-USA TODAY Network via Imagn Images

Philip Rivers Believes in Anthony Richardson Sr.'s Future

Drake Wally

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Dec 19, 2025

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