Commanders vs. Lions Prediction, Odds, Spread, Trends for NFL Preseason Week 2

The Washington Commanders and Detroit Lions are set to face each other in a Week 2 preseason duel between two teams that are hoping to bounce back after disappointing 2025 seasons.

The Commanders crushed the Dolphins 20-7 in their first preseason game, while the Lions came up short to the Bengals, losing 16-14.

Let's dive into the odds and my best bet for Saturday's exhibition showdown.

Commanders vs. Lions Odds, Spread, and Total for Preseason Week 2

Odds via DraftKings Sportsbook

Spread

Commanders +1.5 (-110)
Lions -1.5 (-110)

Moneyline

Commanders +110
Lions -130

Total

OVER 36.5 (-115)
UNDER 36.5 (-105)

Commanders vs. Lions How to Watch Preseason Week 2

Date: Saturday, August 22
Time: Noon ET
Venue: Ford Field
How to Watch (TV): Lions TV Network, WUSA9
Commanders record: 1-0
Lions record: 0-1

Commanders vs. Lions Betting Trends

Dan Quinn is 8-20 straight up and 8-19-1 against the spread as a head coach in the preseason
Dan Campbell is 6-11 straight up and 8-9 against the spread as a head coach in the preseason

Commanders vs. Lions Key Player to Watch

Jacob Saylors, RB - Detroit Lions

There's an opening on the Lions' depth chart for the No. 2 running back spot behind Jahmyr Gibbs with David Montgomery now in Houston. Their second-year running back, Jacob Saylors, made a great impression in their first preseason game, rushing for 55 yards on eight carries. Will he be able to expand his role in the regular season beyond being just a special teams player?

Commanders vs. Lions Prediction and Best Bet

Despite the Commanders' Week 1 win, I can't get past Dan Quinn's record as a head coach in the preseason throughout his career. Meanwhile, I can look past the Lions' Week 1 loss, considering they played none of their starters.

Starters are expected to play at least a portion of this Week 2 game on Saturday, so I'm going to give the edge to the Lions, who managed to cover the spread playing only backups last week.

Pick: Lions -1.5 (-110) via DraftKings

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