Opening Odds for Every NFL Schedule Leak for 2025 Season

Iain MacMillan | May 13, 2025

The Packers and Eagles are scheduled to face off in Monday Night Football in Week 10. / Eric Hartline-Imagn Images

The full NFL schedule is set to be released on Wednesday, May 14, but as we know as long time football fans, some of the biggest games for the upcoming season have already been released and will continue to be released before the entire schedule is made public.

On this page, we're going to give you the opening odds for every single announced game and will update it as more games are released.

2025 NFL Opening Odds

All odds below via DraftKings Sportsbook

Cowboys vs. Eagles Opening Odds (Week 1)

Spread

• Cowboys +7 (-110)
• Eagles -7 (-110)

Moneyline

• Cowboys +250
• Eagles -310

Total

• 46.5 (Over -110/Under -110

Vikings vs. Steelers Opening Odds (Week 4)

Spread

• Vikings -1.5 (-110)
• Steelers +1.5 (-110)

Moneyline

• Vikings -122
• Steelers +102

Total

• 42.5 (Over -110/Under -110)

Vikings vs. Browns Odds, Spread, and Total (Week 5)

Spread

• Vikings -7 (-110)
• Browns +7 (-110)

Moneyline

• Vikings -325
• Browns +260

Total

• 41.5 (Over -110/Under -110)

Broncos vs. Jets Opening Odds (Week 6)

Spread

• Broncos -6.5 (-115)
• Jets +6.5 (-105)

Moneyline

• Broncos -290
• Jets +235

Total

• 41.5 (Over -115/Under -105)

Rams vs. Jaguars Opening Odds (Week 7)

Spread

• Rams -4.5 (-110)
• Jaguars +4.5 (-110)

Moneyline

• Rams -205
• Jaguars +170

Total

• 47.5 (Over -110/Under -110)

Falcons vs. Colts Opening Odds (Week 10)

Spread

• Falcons -1.5 (-102)
• Colts +1.5 (-118)

Moneyline

• Falcons -112
• Colts -108

Total

• 44.5 (Over -110/Under -110)

Eagles vs. Packers Opening Odds (Week 10)

Spread

• Eagles -1.5 (-110)
• Packers +1.5 (-110)

Moneyline

• Eagles -122
• Packers +102

Total

• 45.5 (Over -110/Under -110)

Commanders vs. Dolphins Opening Odds (Week 11)

Spread

• Commanders -3 (-108)
• Dolphins +3 (-112)

Moneyline

• Commanders -155
• Dolphins +130

Total

• 48.5 (Over -110/Under -110)

Bears vs. Eagles Opening Odds (Week 13)

Spread

• Bears +7 (-110)
• Eagles -7 (-110)

Moneyline

• Bears +245
• Eagles -305

Total

• 46.5 (Over -110/Under -110)

Eagles vs. Commanders Opening Odds (Week 16)

Spread

• Eagles -1.5 (-110)
• Commanders +1.5 (-110)

Moneyline

• Eagles -120
• Commanders +100

Total

• 48.5 (Over -105/Under -115)

Packers vs. Bears Opening Odds (Week 16)

Spread

• Packers -1.5 (-110)
• Bears +1.5 (-110)

Moneyline

• Packers -120
• Bears +100

Total

• 45.5 (Over -110/Under -110)

Broncos vs. Chiefs Opening Odds (Week 17)

Spread

• Broncos +4.5 (-110)
• Chiefs -4.5 (-110)

Moneyline

• Broncos +180
• Chiefs -218

Total

• 44.5 (Over -110/Under -110)

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