A starter in every game this fall, Eskridge earned ACC defensive back of the week honors for his performance against Notre Dame, which included nine tackles, a fumble recovery and a 29-yard interception return for a touchdown. He led the Orange secondary with 68 tackles this season.
The Miami, Florida native earned All-ACC third-team honors in 2013 after leading the Orange in tackles and interceptions as a sophomore.
Syracuse finished 3-9 this season.
The university announced Eskridge's decision in a release Tuesday.