If the bracket holds to form, Ohio State would face Duke in one national semifinal with Kansas and Pittsburgh on the other side. The Final Four will be held in Houston, starting April 2.
The final four at-large teams to make the field are Alabama-Birmingham, Clemson, Southern California and Virginia Commonwealth. UAB-Clemson and USC-VCU will play "First Four" games Tuesday and Wednesday in Dayton, Ohio.
Bubble teams that failed to make the 68-team tournament included Alabama, Boston College, Colorado, Missouri State, St. Mary's and Virginia Tech.
No. 1 overall seed Ohio State won the Big Ten tournament 71-60 over Penn State on Sunday afternoon and enters the tournament at 32-2. The Buckeyes seek their first Final Four since freshman Greg Oden led them to the championship game in 2007.
The Buckeyes, leading the East region, open against either Texas-San Antonio or Alabama State on Friday in Cleveland. The other top seeds in the East: No. 2 North Carolina (vs. Long Island), No. 3 Syracuse (vs. Indiana State) and No. 4 Kentucky (vs. Princeton). UAB and Clemson were two bubble teams that made the bracket in the East region. So did Georgia, comfortably, as a No. 10 seed.
This is the fourth No. 1 seed in five years for Kansas, which won the Big 12 tournament on Saturday and boasts an eight-game winning streak and the No. 1 RPI according to collegerpi.com. This is the 10th time KU has claimed a No. 1 seed since the field expanded to 64 in 1985. In that span, the Jayhawks have reached the Final Four seven times and won the national championship in 1988 and 2008.
Kansas will play Boston University in its first game in Tulsa, Okla., on Friday. The No. 2 seed in the Jayhawks' Southwest region is Notre Dame, which many thought had a chance at a No. 1 seed. No. 3 Purdue and No. 4 Louisville are also in the Southwest. Bubble teams Virginia Commonwealth and USC will play a "First Four" game for the right to the No. 11 seed that plays Georgetown.
Pittsburgh won the regular-season Big East championship with a 15-3 mark and enters the tournament at 27-5 overall. This is the second No. 1 seed for coach Jamie Dixon in the last three years.
Pitt leads the Southeast region, followed by No. 2 Florida, No. 3 BYU and No. 4 Wisconsin. Pitt could play No. 8 Butler, the defending national runner-up, in its second game Saturday.
The fourth No. 1 seed went to defending national champion Duke, which routed North Carolina 75-58 in the ACC final on Sunday. Duke was second to UNC in the ACC regular season but won the league tournament with three dominating wins and finished 30-4 overall. Duke's last three national championships (2010, 2001, 1992) all came with the Blue Devils holding a No. 1 seed.
Duke gets Hampton in its first-round game, Friday in Charlotte, N.C., in the West region. Also in the West is No. 2 San Diego State, No. 3 Connecticut and No. 4 Texas. No. 8 Michigan and No. 10 Penn State are two Big Ten teams who may have played their way into the tournament this past week.
The last four national champions have all been No. 1 seeds and a No. 1 has won 16 of the 26 tournaments since the field reached 64 teams in 1985.