Trailing 27-24 in the fourth quarter, the Blue Devils marched 80 yards in 11 plays to take the lead on a 1-yard TD run by Hollomon with 36 seconds left. SanGiacomo was 22 of 28 for 273 yards passing, while Hollomon rushed for 161 yards on 23 carries.
Tyrell Holmes had four catches for 102 yards and a touchdown for CCSU and Brandon Hollomon, younger brother of Rob Hollomon, scored with a 5-yard TD catch.
Towson's Connor Frazier accounted for three touchdowns, including a 49-yard scramble in the fourth quarter, but was held to just 125 yards passing. Darius Victor had 19 carries for 105 yards and a touchdown for the Tigers, who hadn't lost a season opener at home since 1991.